Structure of PDB 1c1v Chain H Binding Site BS01

Receptor Information
>1c1v Chain H (length=252) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
GE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1c1v Design of potent selective zinc-mediated serine protease inhibitors.
Resolution1.98 Å
Binding residue
(original residue number in PDB)		F34 K36 Q38 L40 L65 R73 T74 R75 Y76 I82
Binding residue
(residue number reindexed from 1)		F19 K21 Q24 L26 L60 R68 T69 R70 Y71 I78
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1c1v, PDBe:1c1v, PDBj:1c1v
PDBsum1c1v
PubMed9468142
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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