Structure of PDB 1c1u Chain H Binding Site BS01
Receptor Information
>1c1u Chain H (length=252) Species:
9606
(Homo sapiens) [
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IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
GE
Ligand information
>1c1u Chain I (length=11) Species:
6421
(Hirudo medicinalis) [
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DFEEIPEEYLQ
Receptor-Ligand Complex Structure
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PDB
1c1u
Design of potent selective zinc-mediated serine protease inhibitors.
Resolution
1.75 Å
Binding residue
(original residue number in PDB)
F34 L65 R67 R73 T74 R75 Y76 I82
Binding residue
(residue number reindexed from 1)
F19 L60 R62 R68 T69 R70 Y71 I78
Enzymatic activity
Enzyme Commision number
3.4.21.5
: thrombin.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005509
calcium ion binding
Biological Process
GO:0006508
proteolysis
GO:0007596
blood coagulation
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Molecular Function
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Biological Process
External links
PDB
RCSB:1c1u
,
PDBe:1c1u
,
PDBj:1c1u
PDBsum
1c1u
PubMed
9468142
UniProt
P00734
|THRB_HUMAN Prothrombin (Gene Name=F2)
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