Structure of PDB 1bmm Chain H Binding Site BS01
Receptor Information
>1bmm Chain H (length=258) Species:
9606
(Homo sapiens) [
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IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFG
Ligand information
>1bmm Chain L (length=28) Species:
9606
(Homo sapiens) [
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GEADCGLRPLFEKKSLEDKTERELLESY
Receptor-Ligand Complex Structure
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PDB
1bmm
Crystallographic determination of the structures of human alpha-thrombin complexed with BMS-186282 and BMS-189090.
Resolution
2.6 Å
Binding residue
(original residue number in PDB)
S20 E23 I24 G25 M26 P28 W29 F114 D116 H119 P120 C122 Y134 K135 R137 N159 K202 P204 N205 R206 W207
Binding residue
(residue number reindexed from 1)
S5 E8 I9 G10 M11 P13 W14 F111 D113 H116 P117 C119 Y134 K135 R137 N164 K212 P214 N217 R218 W219
Enzymatic activity
Enzyme Commision number
3.4.21.5
: thrombin.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005509
calcium ion binding
Biological Process
GO:0006508
proteolysis
GO:0007596
blood coagulation
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Molecular Function
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Biological Process
External links
PDB
RCSB:1bmm
,
PDBe:1bmm
,
PDBj:1bmm
PDBsum
1bmm
PubMed
8745399
UniProt
P00734
|THRB_HUMAN Prothrombin (Gene Name=F2)
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