Structure of PDB 1a5g Chain H Binding Site BS01
Receptor Information
>1a5g Chain H (length=250) Species:
9606
(Homo sapiens) [
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IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG
Ligand information
>1a5g Chain L (length=27) Species:
9606
(Homo sapiens) [
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ADCGLRPLFEKKSLEDKTERELLESYI
Receptor-Ligand Complex Structure
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PDB
1a5g
Bound structures of novel P3-P1' beta-strand mimetic inhibitors of thrombin.
Resolution
2.06 Å
Binding residue
(original residue number in PDB)
E23 I24 G25 M26 P28 W29 D116 H119 P120 C122 Y134 K135 R137 N159 K202 R206 W207
Binding residue
(residue number reindexed from 1)
E8 I9 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N156 K204 R210 W211
Enzymatic activity
Enzyme Commision number
3.4.21.5
: thrombin.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005509
calcium ion binding
Biological Process
GO:0006508
proteolysis
GO:0007596
blood coagulation
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Molecular Function
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Biological Process
External links
PDB
RCSB:1a5g
,
PDBe:1a5g
,
PDBj:1a5g
PDBsum
1a5g
PubMed
10212123
UniProt
P00734
|THRB_HUMAN Prothrombin (Gene Name=F2)
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