Structure of PDB 4v8p Chain GY Binding Site BS01

Receptor Information

>4v8p Chain GY (length=102) Species: 5911 (Tetrahymena thermophila)

AKRTQKVGITRKYGTRYGASLRKVVKKFEITQHAKYGCPFCGKVAVKRAA
VGIWKCKPCKKIIAGGAWELTTPPAVTAKTTMNRLKKLQEEQAAAAALEK
KN

Ligand information

>4v8p Chain H1 (length=3119)

cuacaccugaaacaagcaagauuacccgcugaacuuaagcauaucaguaa
gcggaggaaaagaaacuaacuaggauagccccaguaauggcgaaugaaca
ggcuaaagcucaaagugaaaaucugaaguggucaacacaacagaauugua
aucuaaagggucaaccugaaacuaagcuccucucauaaguuccuuggaac
aggacgucaaagagggugacaaccccguagucggagaggaaggcuggugu
aagggagauuucaaagagucggguuguuugggauugcagcccuaaguggg
agauaaacuucuucuaaagcuaaauauacacgggagaccgauagcgaaca
aguacugcgaaggaaagaugaaaagaacuuugaaaagagggcuaaaagac
uugaaaccguugagaaggaagcuguagaagagcaauaaacuggacggcgc
auaagggggaaguacuaaucacugcagagucgauacguaaaaggucgaug
aguaaggaaaugguacagaacuugcuacgccggucagaagacaaaauggg
uucagauugaaggagucaccugagaucgggcagcaaugcagaucaaaagg
aaaacuucaaacuggacugaggggccuaagggcgauuuugucaaaauggc
uucuacugacccgucuugaaacacggaccaaggagucuaucaauuaagcg
agugauaggguggaaaaacccguccgcgaaacgaaagugaguacaaggug
ccaagccgcaagguagcagcaucacccgaccuugagucuccgacgaaggg
uucgaggaagagcuuaauuguuaggacccgaaagauggugaacuacgcuu
gaauagggugaagccaggggaaacucugguggaagcucguagcgauacug
acgugcaaaucguucgucaaauuugaguguaggggcgaaagacuaaucga
accaucuaguagcugguucccuccgaaguuucucucaggauagcaagagc
aaguacgcaguuuuauuagguaaagcgaaugauuagaggacucgggguuc
caagaaucucgaccuauucucaaacuuuaaauugguaagagccgcggagu
uuacuuaaaugaacucucgggaagaaugcagugcucuuagugggccauuu
uugguaagcagaacuggcgaugagggaugaaccuaacguugagauaaggc
gcccaaaugcacgcucaucagauaccacaaaagguguugguucauacgga
cagcaggccugccgaaugaacuagcccugaaaauggauggcgcugaagcg
uguugccgauacucaaccaucagagcaaaugcgaggcuuugaugaguagg
agggcgugaucguugccuagaaguauugggcgugagccuauauggagcag
cgauuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuu
gaagaccgaaguggagaaggguuccaugagaacagcaauuguucaugggu
uacucgauccuaagacauagguuaacuccuugcaauacaagaagacauuc
guuuucguugucaaaagggaaugagguuaauauuccucaagcuggacgug
guauagagcgguaacgcaaagaaacccggagacgucagcaggugucacug
gaagaguuaucuuuucuuuuuaacauacuauggccaugaaauuggauuau
ccagagauaucggcuguauguauggcagagcagcucagagcugucaguug
cgcaccugaugacccuugaaaaucugggggagacauaauuucacgccagu
ucguacccauaaccgcaucaggucuccaagguuagcagccucugguccau
agaacaauguagauaagggaagucggcaaauuggauccguaacuucggga
uaaggauuggcucugaggaucucagaacugaagcggacaaagguaauccg
acuguuuaauaaaaacaaagcauugugacggccucaacaggugaugacac
aaugugauuucugcccagugcucugaaugucaaagugacgcaauucaacc
aagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaa
ugccucgucaucuaauuagugacgcgcaugaauggauuaaugagauuacc
acugucccuaucuacuaucuagcgaacccacagcuaagggaacgggcuua
gaauaaucagcggggaaagaagacccuguugagcuugacucuagucuaac
uuugugaaauggcagucauuuugcuuauuucgugaagaaaagacuggugc
aaaccaguucuaaaguuaaggucauuuauugacugauuuuugcgaaagac
augguuagggggggaguuugucuggggcggaaugccuguuaaaccauaac
gcaggcguccuaaguguagcucagugagaacggaaaucucacguagaaca
aaaggguaaaagcuacauugauuuugauuuucaguaggaauacaaaccgc
gaaagcguggccuaucgauccuuuaacuuuacaaguuuuaagcuagaggu
gucagaaaaguuaccacagggauaacuggcuuguggcagccaagaguuca
uaucgacguugcuuuuugauccuucgaugucggcucuuccuaucauugug
aagcagaauucacaacgugucggauuguucacccgcuaauagggaacgug
agcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaa
acgauguugcgacaguaauuuaaguuaguacgagaggaacacuuaaauca
gauaauugguaaauacgguugucugaaaagacaaugccgugaagcuacca
ucuguuggauuaugacugaaggccucuaagucagaauccaugcuggaaag
caaugucuaagugugaugauaaacgaaaaaaaauaaaaauuaaguucgaa
agguagagcggggaagagcgaaaaagcuugaccuuaacugcuaaucguaa
uuccaaauuaucaucuacguaaaucuuuuguagacgacuuaacauggaac
ggguauuguaagcaugagaguagaauuuccuacgaucugcugagauucag
cccgucuccuuagauuuau

........................<<<<<<.....<......>......>
>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....
>>>>>..[[[...........<<<<..<<<.....>>>..>>>>......
.......<<<<<..<<<...<<<.<<<<<<<<<<......<<<<......
>>>>.((......<<<.....))>>>.......>>>>>>>..>>>>>>..
.>>>..>>>>.>........<<<<<<<........>>>>>>>.....(((
((..<<<<<<)))))..]]]....}.........................
....<<....>>...............<<<<....>>>>...........
.....................<.<<<<<<<....<<...<<<<.<<<<<.
....<<<....<<<<<.<<..<<<<...<<<<<<.<......>>>>>>>.
.>>.>>...>>>>>>>....>>>....>>>>>.>>>>..<<<<<<<<.<<
<<<<<.<<<<<<......<<<..<<<<..<<<....>>>.>>>>...>>>
....>>>>>>.>>>>>>>.....<<<....>>>.>>>>>>>>...>>..>
>>>>>>.>..<<<<........>>>><<<<<<...<<<<.<<<<<<<<<.
.<<<...<<<<......>>>>...>>>...<<....>>........<<<<
<...<<<....>>>....>>>>>.<<<<<<<....<<<...>>>....>>
.>>>.>>....>>>>>>>>>.>>>>.<<.<...<<<<<<.....<<<<<<
<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<
<........>>>>>>>>....>>>>>>>>>...<<.......>>......
>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<
<.....<<<.<<<<<<<<<...<<<....<<<....<<<..<<<<<<<<<
...>>>>>>>>>>>>....>>>..>.>>...>>>>>>>...<<<.<<<<<
<..........>>>>>>>>>....>>>>>..>>>>>>>.>>..<<<<.<<
<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<....<<<
(((.....<<<<<<......<..........<<<.<<<<<<<<<......
..<<<<..>>>>....>>>>>>>>>>>>..........))).>....>>>
>>>.>>>....>>>>>><<<<<<<<<.........>>>>>>>>>....>>
>>>><.<<<<<<<<<<......<<<<.<<<<....>>>>>>>>...>>>>
>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>
>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>..
..((<<<<<<...<<<..<<<......>>>..........<<<<<<....
>>>>>>...>>>....>>>..<<<<<........>>>>>))<<<<.<<<<
..<<...<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<
<<<<<<.......>>>>>><...<<<<<...<<<<<<<....<<<<...>
>>>....>>>.>>>>....>>>>>....><<<<<<<.>>>>>>>>>>>.>
.>>>>>>>.>>>>.........>>>>>>.........>>..>>>>>>>>.
>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<
<<<.....<<<<<<<.<<...............<<<<<............
...>>>>><<.<<<<<<...>>>>>>.>>............<<<<<<<<<
..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>
>>>>>...<<..<<<..<<<<<<....<<<.....<<<......>>>...
..>>>.>>>>..>>>>><<<<<<.......>>>>>>........<.....
......<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>
.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>
>....(((((..{{{.{{......[[[[.{{[[[[..<<<<<..<<<<<<
<..<<<<<<<<<<.>>>>>>>>>>...<<<<<.....<<<<..<<<<<..
..>>>>>............<<<<<.....>>>>>..>>>>..>>>>>...
..>>>>>>>...>>>>>...<<<.....>>>..<<<<<<...........
>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.
..(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<
....>>>.>>))).......(((((.[.(((.>>>>>>)))].)))))..
........]]]]..}}]]]].......<<.<...<<<<<<...<<.....
..>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<<<<<<<
<<......>>>>>>>..>>.<<<.........>>>.....>>>>>..>..
.>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.)))))...
..<<<<<<<<..<<<<.<<<<<<<<...............>>>>>>>><<
<<<...<<<<....<<<<<<<<<<....>>>>>..>>>>>...>>>>..>
>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>
>>>>>>>.....<<<<<<<<......<<................>>....
..<<<<...<<<...<<<<......>>>>..>>>...>>>>.........
......>>>>>>>>....<<<<<<<<<.............>....<<<<<
<<<.<<<....<<<.<<..<<<<......>>>>..>>>>>...>>>....
>>>>>.>>>..>>>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4v8p Crystal Structure of the Eukaryotic 60S Ribosomal Subunit in Complex with Initiation Factor 6.
• Resolution: 3.52 Å
• Binding residue (original residue number in PDB): A2 R4 T5 Q6 K7 V8 G9 I10 R12 K13 T16 R17 Y18 G19 A20 S21 R23 H34 K36 K44 R49 A50 A51 V52 K62 W69
• Binding residue (residue number reindexed from 1): A1 R3 T4 Q5 K6 V7 G8 I9 R11 K12 T15 R16 Y17 G18 A19 S20 R22 H33 K35 K43 R48 A49 A50 V51 K61 W68

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4v8p, PDBe:4v8p, PDBj:4v8p
• PDBsum: 4v8p
• PubMed: 22052974
• UniProt: Q23G98|RL37A_TETTS Large ribosomal subunit protein eL43 (Gene Name=RPL37A)