Structure of PDB 8w2o Chain G Binding Site BS01

Receptor Information
>8w2o Chain G (length=232) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFDIWKNLDRIRSTKKNAGQFIKGSLLILPMRTEDKQQFDECMDELHKYI
SKDILRCYPQKMLFYIVLKDFNILDSCFVLSVLLAFQKRLWMAPSEKSYF
RVPKNINLTGSFYLPKNIETGSSIVEVGFNVVPDFQQFQVKACHVSKFMN
ELSNFFSQVEFGKCEANVINYFKREYNRTYSQISLALYELPLIGDGLFDI
KSYISKTRPIIETSKAQMIKHISEMKAYNEIS
Ligand information
>8w2o Chain R (length=327) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
accuuaagauaucagaggaaaguccuacugaucaaacaugcgcuuccaau
aguagaaggacguuaagcauuuaucauugaacuguucauugaagucauug
augcaaacuccuuggucacacacacauacggcgcggaaggcguguuugcu
gacguuuccauucccuuguuucaaucauugguuaaacugauuuuuggggc
ccuuuguuucuucugccuggagaaguuugacaccaaauucaaauuggugu
uaggggagcuggggccuuucaaaaaaauuuuggaaggucuugguaggaac
ggguggaucuuauaauuuuugauuuau
.....<<<<.<<<<<<<<.....>>>.>>>>><<<<<<<<<.<<<<<...
.....<<<<<.<<<..<<<<.<.<<<.<<<<<.>>>>>.>>>.......>
>>>>.>>>>>>>>.....................>>>>>>>>>>>>>><<
<.<<<<.<<..<<<<<.<<<<<<<..<<<<<<<.>>>>>>>..>>>>>>>
((.......<<<<<....))>>>>>...<<<<<<<<.<....>>>>>>>>
>.>>>>><<<<<<<<<<<<<<<<<...>>>>>>>>>>>>>>>>>.>>>>>
>..>>>.>>>>................
Receptor-Ligand Complex Structure
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PDB8w2o Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeast.
Resolution3.49 Å
Binding residue
(original residue number in PDB)		N166 G225 K226 K236
Binding residue
(residue number reindexed from 1)		N117 G162 K163 K173
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
Biological Process
GO:0000395 mRNA 5'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0000243 commitment complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005685 U1 snRNP
GO:0071004 U2-type prespliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8w2o, PDBe:8w2o, PDBj:8w2o
PDBsum8w2o
PubMed38688558
UniProtQ03782|SNU56_YEAST 56 kDa U1 small nuclear ribonucleoprotein component (Gene Name=SNU56)

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