Structure of PDB 8s8f Chain G Binding Site BS01

Receptor Information
>8s8f Chain G (length=230) Species: 284590 (Kluyveromyces lactis NRRL Y-1140) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKLNISYPINGTQKCIEIDDEHRVRVFYDKRIGQEVDGESVGDEFKGYVF
KIAGGNDKQGFPMKQGVLLPTRVKLLLAKGHSCYRPRRNGERKRKSVRGA
IVGPDLAVLALIITKKGEQEIEGITNDTVPKRLGPKRANNIRKFFGLTKE
DDVRDYVIRREVTKGDKSYTKAPKIQRLVTPQRLQRKRQQKSLKIKNAQA
QREAAAEYAQLLAKRLSERKAEKAEVRKRR
Ligand information
>8s8f Chain 2 (length=1789) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuuacuacauggauaucug
ugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagag
auguauuuauuagauaaaaaaucaaugucuucggacuccuugaugauuca
uaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaa
uuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuuc
aacggguaacggggaauaaggguucgauuccggagagggagccugagaaa
cggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccua
auucagggagguagugacaauaaauaacgauacagggcccauucgggucu
uguaauuggaaugaguacaauguaaauaccuuaacgaggaacaacuggag
ggcaagucuggugccagcagccgcgguaauuccagcuccaguagcguaua
uuaaaguuguugcaguuaaaaagcucguaguugaacuuugggucugguug
uccgguccgcgcgcacugguuuucaaccggaucuuuccuucuggcuaacc
uguacuccuugugggugcaggcgaaccaggacuuuuacuuugaaaaaauu
agaguguucaaagcaggcgaaagcucgaauauauuagcauggaauaaugg
aauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugau
uaauagggacggucgggggcaucaguauucaauugucagaggugaaauuc
uuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuu
ucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccguc
guagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuucu
uaugacccacucggcaccuuacgagaaaucaaagucuuuggguucugggg
ggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcacca
ccaggaguggagccugcggcuuaauuugacucaacacggggaaacucacc
agguccagacacaauaaggauugacagauugagagcucuuucuugauuuu
gugggugguggugcauggccguucuuaguugguggagugauuugucugcu
uaauugcgauaacgaacgagaccuuaaccuacuaaauaggguugcuggca
cuugccgguugacucuucuuagagggacuaucgguuucaagccgauggaa
guuugaggcaauaacaggucugugaugcccuuagacguucugggccgcac
gcgcgcuacacugacggagccagcgaguacaaccuuggccgagaggucug
gguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauu
gcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguuga
uuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaau
ggcuuagugaggccucaggauuugcuuagagaagggggcaacuccaucuc
agagcgaagaaucuggucaaacuuggucauuuagaggaacuaaaagucgu
aacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<................<<.....<<.
<<<.....>>>.>>......>>........<<<<<..<<....>>..>>>
>><...<<<<<<......(((((((.<<<....>>>....<........>
>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>
>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>...
...>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<........
..>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.
....>>>..>>>..>....>.>.....<<.<<<<<<<..........>>>
>>>>..>>......<<..<...........>..>>.........<<<<<(
(......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>
>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<<
.<<<<<.<..>...>>>>>....>>>>>>>>>>>....<<<<<<....<.
<<.<<<.......>>>.>>.>....>>>>>>...<<<<<.<<.......<
<...<.......>..<<<....>>>....>>......>>.>>..>>>...
......<<<..<<<<<<<<.....))))))).>>>>>>>>.>>>.....>
>....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>
......>.>>>>>>.>>>.......<<....>>...>>>>...>>>>>.>
>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>
...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.....
...>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<
<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<
<.<<<<<<..<<<.<<<<<<......<<........>>..........<<
<<<.<....<<<<<........<<.<<<........>>>.>>......>>
>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<.
.....>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<<<<<<<<.
...>>>>>>.>>>>>>..>>>>.>>....<<<<<<.....>>>>>>....
...>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>
>>>.>>>.....<<<<<<<......<<.....<<<.<<<<....>>>>.>
>>....>>.......>>>>>>>......<....<<<<<<..........>
>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>..
....>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<
<<<<.<<<..<<<<..<...<<<<<<........................
..>>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>.
..>.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8s8f Structural basis of AUC codon discrimination during translation initiation in yeast.
Resolution3.95 Å
Binding residue
(original residue number in PDB)		K2 N4 S6 Q13 C15 R31 A53 G54 N56 K58 Q59 G60 F61 Q65 G66 L68 R72 L75 L76 C83 Y84 R87 R88 G90 E91 R92 R94 K95 S96 V108 K131 R132 L133 G134 P135 K136 R137 N139 N140 K143 R154 R159 R160 K164 K167 Y169 K171 A172 P173 K174 I175 Q176 R177 L178 V179 Q182 R183 L184 Q185 R186 K187 R188 Q190 S192 K194 I195 A198 Q201 R202 K220
Binding residue
(residue number reindexed from 1)		K2 N4 S6 Q13 C15 R31 A53 G54 N56 K58 Q59 G60 F61 Q65 G66 L68 R72 L75 L76 C83 Y84 R87 R88 G90 E91 R92 R94 K95 S96 V108 K131 R132 L133 G134 P135 K136 R137 N139 N140 K143 R154 R159 R160 K164 K167 Y169 K171 A172 P173 K174 I175 Q176 R177 L178 V179 Q182 R183 L184 Q185 R186 K187 R188 Q190 S192 K194 I195 A198 Q201 R202 K220
External links
PDB RCSB:8s8f, PDBe:8s8f, PDBj:8s8f
PDBsum8s8f
PubMed39193907
UniProtQ6CM04|RS6_KLULA Small ribosomal subunit protein eS6 (Gene Name=RPS6)

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