Structure of PDB 8r08 Chain G Binding Site BS01

Receptor Information
>8r08 Chain G (length=579) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EAKPKFLSKAEREAEALKRRQQEVEERQRMLEEERKKRKQFQDLGRDKSK
ELHAIKERYLRKFVFEWDASEDTSIDYNPLYKERHQVQLLGRGFIAGIDL
KQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQ
KKLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKC
GYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKI
DRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISRE
DQGFRLRMGEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFE
PDVQKILEHMPVSNQKPDTDEAEPEKMLANFESGKHKYRQTVMFTATMPP
AVERLARSYLRRPAVVYIGKPHERVEQKVFLMSESEKRKKLLAILEQGFD
PPIIIFVNQKKGCDVLAKSLEKMGYNACTLREFALSNLKAGAKDILVATD
VIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVF
YELKQAILESPVSSPPELANHPDAQHKPG
Ligand information
>8r08 Chain 1 (length=153) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcaggggagauaccaugaucacgaaggugguuuucccagggcgaggcuua
uccauugcacuccggaugugcugaccccugcgauuuccccaaauguggga
aacucgacugcauaauuugugguagugggggacugcguucgcgcuuuccc
cug
<<<<.<<<<<.<<<<<..........>>>>>>>>>>.<<<<...<<<.<<
<<<..........>>>>>.>>>...>>>>.<<<<<<<<<.......>>>>
>>.>>>.>>>>...............<<<<<<..<<<<..>>>>..>>>>
>>.
Receptor-Ligand Complex Structure
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PDB8r08 Structural insights into the cross-exon to cross-intron spliceosome switch
Resolution6.1 Å
Binding residue
(original residue number in PDB)		K682 S683
Binding residue
(residue number reindexed from 1)		K468 S469
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003729 mRNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000354 cis assembly of pre-catalytic spliceosome
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0062176 R-loop processing
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0070062 extracellular exosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8r08, PDBe:8r08, PDBj:8r08
PDBsum8r08
PubMed38778104
UniProtQ9BUQ8|DDX23_HUMAN Probable ATP-dependent RNA helicase DDX23 (Gene Name=DDX23)

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