Structure of PDB 8qrk Chain G Binding Site BS01

Receptor Information

>8qrk Chain G (length=322) Species: 9606 (Homo sapiens)

RHTAFVIPKKNVPTSKRETYTEDFIKKQIEEFNIGKRHLANMMGEDPETF
TQEDIDRAIAYLFPSGLFEKRARPVMKHPEQIFPRQWGEDGRPFHYLFYT
GKQSYYSLMHDVYGMLLNLEKHQVIGSRWLIKEELEEMLVEKLSDLDYMQ
FIRLLEKLLTSQCGAAEEEFVQRFRRESKKQLIEPVQYDEQGMAFSKSEG
KRKTAKAEAIVYKHGSGRIKVNGIDYQLYFPITQDREQLMFPFHFVDRLG
KHDVTCTVSGGGRSAQAGAIRLAMAKALCSFVTEDEVEWMRQAGLLTTDP
RVRERKKPGQEGARRKFTWKKR

Ligand information

>8qrk Chain A (length=955)

aauagguuugguccuagccuuucuauuagcucuuaguaagauuacacaug
caagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaa
gggacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagc
cacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaag
uuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccac
cgcggucacacgauuaacccaagucaauagaagccggcguaaagaguguu
uuagaucacccccuccccaauaaagcuaaaacucaccugaguuguaaaaa
acuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaa
cacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuag
cccuaaaccucaacaguuaaaucaacaaaacugcucgccagaacacuacg
agccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuag
aggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuug
cucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaag
uaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugag
guggcaagaaaugggcuacauuuucuaccccagaaaacuacgauagcccu
uaugaaacuuaagggucgaagguggauuuagcaguaaacugagaguagag
ugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuc
cucaaguauacuucaaaggacauuuaacuaaaaccccuacgcauuuauau
agaggagacaagucguaacaugguaaguguacuggaaagugcacuuggac
gaacc

...((((..<<<<<<.)))).<<<<<<.<...<<<<<<<<..<.<<<.<<
<..<......>......<<.......<<<<.<..<<.......>>.>..>
>>>..<<<<....<<...<<<....>>>..>>......>>>>.<<...>>
.>>.<<......>>.....>>>>>>>........<<<....<<<<....>
>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>
>)).......)))..>>>>>...>.>>>>>>....<<<((.....<<<<.
.<<<<...............<<<<<<......<<<.<<<.<<<......>
>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>..
.>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>
>..........<.<<<<<......))..>>>>>.>.>>>.<<.......<
<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<
<..<<<<<<<<<<.....<<........>>..........<<<<<<<...
....<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>
>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>
>>>>..>>.>>>>>>>>.....<<<<.....>>>>.....<....<<<<<
<<.......>>>>>>>....>.....>>>>>.....<<<<<<<.......
..>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<
<<<..<<<<<......<<<...<<<.....>>>..>>>.......>>>>>
.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>....
.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8qrk GTPBP8 plays a role in mitoribosome formation in human mitochondria.
• Resolution: 6.69 Å
• Binding residue (original residue number in PDB): R50 H51 F117 E118 L216 Q220 R276 K277 T278 I306 G336 R337 S338 A339 R375 V376 R377 E378 R379 K380 K381 P382 R388 R389 K390 F391 T392 W393 K394 K395 R396
• Binding residue (residue number reindexed from 1): R1 H2 F68 E69 L146 Q150 R202 K203 T204 I232 G262 R263 S264 A265 R301 V302 R303 E304 R305 K306 K307 P308 R314 R315 K316 F317 T318 W319 K320 K321 R322

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005730 nucleolus
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8qrk, PDBe:8qrk, PDBj:8qrk
• PDBsum: 8qrk
• PubMed: 38969660
• UniProt: P82933|RT09_HUMAN Small ribosomal subunit protein uS9m (Gene Name=MRPS9)