Structure of PDB 8ovj Chain G Binding Site BS01

Receptor Information
>8ovj Chain G (length=226) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HFAARPKNFGIGQDVPYARDLSRFMRWPTFVTMQRKKRVLQRRLKVPPAL
NQFTKVLDRASRNEALKLIKKYAPETRKARRERLQKVAEKAPLAVVTGLQ
EVTRAIEKKQARMVVIANNVDPVELVLWMPNLCRANKIPYAIVKDMARLG
DAIGRKTATCVALTDVNAEDEATLKNLIRSVNARFLSRSDVIRRQWGGLQ
LSLRSRAELRKKHARNAGVDAAAIIQ
Ligand information
>8ovj Chain 1 (length=1611) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cagaccugaguguggcaggacuacccgccgaacuuaagcauauuacucag
cggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaaga
gggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggc
acgugugguuggugcaggaguggcgaaauucaagcgaaaagcaaacccgu
ugcugaauacaacccuucaugugaguauugagccaaagaagguguuagcc
cauugagccauaaaccugagcgccucaugaacaagcgaguagcacuguuu
gggaaugcagugucaaguggcagguauuugucugccaaaguuaaauacag
aguaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaagc
acuuuggaaagagagugaaauagaaccugaagucgugacaaagacaaugg
aaguaccuccauuucaacggccagaaccagcccuacugcauuauccuguc
ggggaucaaaauccggcgggcaacgaagugcaagaaugggucuuggugaa
augagcggaguauuugugcugcgcacggcggccgcacgcacugguuucuu
cuccgugaugcuccauguuggcgauggaaauggggugcccccacccgucu
ugaaacacggaccaaggagucaaacagacgcgcaagggaggagauaugcc
aguacuucucucguacugaaagggagaugcaaaaugcaucuguggugugc
acacgucaaauccguuugauuugcccaacaccgaccggcccuccgugggu
ugcguuggagugugccuguuuggacccgaaagguggugaacuaugccuga
acaaggugaagcccggggaaacccagguggaggccuguagcgaugcugac
gugcaaaucgcucguaugauuuggguaucggagcgaaagacucaucgaac
caccuaguagcugguucacaucgaaguuucccucaggauagcuggugcua
guagaaguauugugcgguaaagcaaaugauuagaggcgaccuauucucaa
acuuuaaaugugcaaacaaaccggccuuagccaacugcaaggccggaaag
aaaagaauuagaggcaccaagugggccuucuucgguaagcggagcaggcg
augcggaaugaaccgcuuagggauauguggcgucaaaacuuaugggcuca
uucucgauacgugaaaaggguugguggauccaccggccccgaaaauggau
gacgcuuaagcccaauuagugauugcccauuauuccuuugguaagggcgg
aaacaaaggagaaaguguagcccuuccgauguagauguggccuggagguu
aggacgaagcuuauggcgugagccuaagauggaccggccucuagugcaga
ucuugguuggcguagcaaagaucuaacggagauauacucaacaugcaacg
uuggauacuggagcggggaaggauuucgugccaacggcacucguacacga
guuguucggaaacugagcacaacguuauaucguuuuguuaggaaagugaa
ggaacugaaaaggggcaacagagaaccugggauuauauuccaaaaagaaa
uugcauguggg
.......................<<<<<......<......>.......>
>>>.>.........<<....>>..<<<<<<......<<.....>>....>
>>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>
>..<<<<...<<<<<<<<.<<<<<......<<<......<<<<.......
>>>>.....<<........>>......>>>.<<.......((.....>>)
).....>>>>>...>>>..>>>>>.>>>>............<<<<<<<..
......>>>>>>>.....<<<<<........>>>>>..>>>.........
...........................<<....>>...............
.<<<<....>>>>..................................<<<
..<<<<<<.<<<<<...<<.<<<<.<<<<<<<<....<<<<<..<<<<<<
<<<........>>>>>>>>>.....>>.>>>......>>>>..>>>>...
.....<<<<<.....<.<<<<.<<.<<<<.>>>>...>>.>.>>>..>..
>>>>>.....<<<<...>>>>>>....>>>>>>>>>>>..>>>.<<<<..
......>>>><<<<<<....<<<<<<<.<<<<<..<<<<..<<.<.....
...>>>..>>>>...<<....>>..<<<<<.....>>>>>...<<<<<..
.<<.<<<<<<....>>>>>>.>>....>>>>><<<<<<<<<.....>>>>
>>.>>>...>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<
<..<<<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<.
.......>>>>>>>>....>>>>>>>>>...<<.......>>......>>
>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.
....<<...<<<<<<....<<<....<<<..<.<<<...>>>.>..>>>.
.>.>>....>>>>>>.....<<<<<<<<.<<.....>>>>>>>>>>....
.......>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>.
..<<<<......>>>>..<<<<<<<...<<<(((......<..<<<<...
.....<...........<<<<<<<<<<..>>>>>>>>>>...........
))).>....>>>>.>.........>>>...>>>>>>><<<<.<<<<<...
.......>>>>.........>>>>>>>>>....>>>>>..<.<<<<<<<<
........<<<<..<<<....>>>.>>>.>.....>>>>>>>>..>....
.>>>>>>..............<<<<<<<....................>>
>>>>>....................<<<<<....<<.....>>..>>>>>
....<<..........<<.<<<<<......>>>>...............<
<...>>......>.>>..........<<<<.........>>....>>.>>
...........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ovj Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		R52 T55 R103 R106 G136 L137 Q138 E139 R142 D159 L163 M184 R193 K194 T197
Binding residue
(residue number reindexed from 1)		R26 T29 R77 R80 G98 L99 Q100 E101 R104 D121 L125 M146 R155 K156 T159
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0000470 maturation of LSU-rRNA
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ovj, PDBe:8ovj, PDBj:8ovj
PDBsum8ovj
PubMed38722744
UniProtQ4QIP1

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