Structure of PDB 8om2 Chain G Binding Site BS01

Receptor Information

>8om2 Chain G (length=203) Species: 4932 (Saccharomyces cerevisiae)

EKGVDEWLEAINELREEFSAKEYLPETSLAPPGQSKVDLLGSKIKPTAEQ
LAQWEALKSVPIPPRKNATLDHITNMIMRHGKKEKAQTILSRALYLVYCQ
TRQDPIQALEKSLDELAPLMMTKTFNTGVAKASVIPVPLNKRQRNRIAWN
WIVQSANQRVSSDFAVRLGEELTAIAKGTSSAFEKRDQIHKTAIAHRAYI
QLK

Ligand information

>8om2 Chain r (length=1486)

auaagaauaugauguugguucagauuaagcgcuaaauaaggacaugacac
augcgaaucauacguuuauuauugauaagauaauaaauaugugguguaaa
cgugaguaauuuuauuaggaauuaaugaacuauagaauaagcuaaauacu
uaauauauaaaaaggauauauaauauauuuaucuauagucaagccaauaa
ugguuuagguaguagguuuauuaagaguuaaaccuagccaacgauccaua
aucgauaaugaaaguuagaacgaucacguugacucugaaauauagucaau
aucuauaagauacagcagugaggaauauuggacaaugaucgaaagauuga
uccaguuacuuauuaggaugauauauaaauauauauauauaaauugauua
aaaauaaaauccauaaauaauuaaaauaaugauauuaauuaccauauauu
uuuauauggauauauuuuaauaguccugacuaauauuugugccagcaguc
gcgguaacacaaagagggcgagcguuaaucauaaugguuuaaaggauccg
uagaaugaauuauauauuauaauuuagaguuaauaaaauuaauuaaagaa
uuauaauaguaaagaugaaauaaauaauuauaagacuaauauaugugaaa
auauuaauuaaauauuaacugacauugagggauuaaaacuagaguagcga
aacggauucgauacccguguaguucuaguaguaaacuaugaauacaauua
uuuauauauauauauauaaauaauaaaugaaaaugaaaguauuccaccug
aagaguacguuagcaauaaugaaacucaaaacaauagacgguuacagacu
uaagcaguggagcauguuauuuaauucgauaauccacgacuaaccuuacc
auauuuugaauauuauaauaauuaaauuauuauauuacaggcguuacauu
guugucuuuaguucgugcugcaaaguuuuagauuaaguucauaaacgaac
aaaacuccauauauauaauuuuaauuauauauaauuuuauauuauuuauu
aauauaaagaaaggaauuaagacaaucauaaugauccuuauaauaugggu
aauagacgugcuauaauaaaaugauaauaaaauuauauaaaauauauuua
auuauauuuaauuaauaauauaaaacauuuuaauuuuuaauauauuuuuu
uauuauauauuaauaugaauuauaaucugaaauucgauuauaugaaaaaa
gaauugcuaguaauacguaaauuaguauguuacggugaauauucuaacug
uuucgcacuaaucacucaucacgcguugaaacauauuauuaucuuauuau
uuauauaauauuuuuuaauaaauuuauuaauuuauauuuauuuauaucag
aaauaauaugaauuaaugcgaaguugaaauacaguuaccguaggggaacc
ugcggugggcuuauaaauaucuuaaauauucuuaca

....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<
.<<<..<<<..<<<<<<<<<<<<.....>>>>>>>>>>..>>>>>.....
<<<........<<<<<.<<.........<<<<<<<<.<<<<.......>>
>>...........<<<<<<<<.>>>>>>>>.>>>>>>>>....>>>>>>>
<<<....<<<..<<<<<<<<........>>>>>>>>>>>......>>>..
<<<<.<<<<....>>>>...>>>>.>>><<<<<<.........>>>>>><
<<<.....>>>>..>>>>>>.........<<<....<<<<....>>>>..
>>>..>>.>>>>>>.<<<<..<<<<<<........>>>>>>..<<.....
.>>.....>>>>..<<<<<<<<..............>>>>><<<<<<<..
..>>>>>>><<..>>>>>....<<<<<(((.....<<<<.....<<.)))
>>.......>>>>.>>>>>..>>>>>>>>>.....<<<((.....<<<<.
..<.<<.<<<<<<<...>>>>>>>...<<<<<<<<...<<<<<<<<<<..
<<<<<<<...................>>>>>>>..>>.......<<....
>>.>>>>>>>>.>>>>>>>>...>>>...>>>>....<<<<<<...<<..
.<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<
<<<<<<<<<..>>>>>>>>>>>>>..<<..))>>....>>>>>>.>>>.<
<.......<<<<....>>>>.....>>..)))).]<<.<<...<<<<...
.<.<<<<<..<<<<<<<<<<............................<<
<<<<<.....<<.<<<<<<<<<<.>>>>>>>>>>.>>.<<<.<<..<<<<
<<<<<<<<..<<<<<<<<<....>>>....<<......>>....>>>>>>
.....<<<.<<<<<<<<........>>>>>>>>..<<<<<<<<<.....>
>>>>>>>>....>>>...>>>>>>>...>>>>>>>>>>...>>>>>>>..
.>>.>>>>>>>>.....<<<<<<........<<<..<<..<<<<<<....
..>>>>>>..>>....>>>......>>>>>>......<<<<<........
>>>>>..........<....<<<<<<<........>>>>>>>....>...
..>>>>>.....<<.<<<<<.........>>>>>>>.....>.....>>>
>..>>..>>....<.<<<.<.<<<<<<<<..<<<<<<<<<.<<<...<<<
..<<<.<<<<<...<<<<<<<..>>>>>>>...>>>>>>>>..>>>..>>
>>>>>>>>>>..>>>>>>>>..>.>>>..>.....<<<<<<<<<....>>
>>>>>>>.............................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8om2 METTL17 is an Fe-S cluster checkpoint for mitochondrial translation.
• Resolution: 2.57 Å
• Binding residue (original residue number in PDB): H116 N119 M122 R123 H124 G125 K126 K127 E128 K129 F169 N170 T171 R186 Q187 R190 S206 F208
• Binding residue (residue number reindexed from 1): H72 N75 M78 R79 H80 G81 K82 K83 E84 K85 F125 N126 T127 R142 Q143 R146 S162 F164

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003729 mRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8om2, PDBe:8om2, PDBj:8om2
• PDBsum: 8om2
• PubMed: 38199006
• UniProt: P47150|RT07_YEAST Small ribosomal subunit protein uS7m (Gene Name=RSM7)