Structure of PDB 8kal Chain G Binding Site BS01 |
| >8kal Chain G (length=1326) Species: 301447 (Streptococcus pyogenes serotype M1)
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KYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLF
DSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLEE
SFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRL
IYLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINA
SGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLIALSLGLTPNFK
SNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLS
DILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFD
QSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQR
TFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVG
PLARGNSRFAWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLP
NEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDLLF
KTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKIIKD
KDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKR
RRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSLT
FKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKVVDELVKVMGR
HKPENIVIEMARNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYL
YYLQNGRDMYVDQELDINRLSDYDVDAIVPQSFLKDDSIDNKVLTRSDKN
RGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDK
AGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLV
SDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDG
KATAKYFFYSNIMNFFKTEIKRPLIETNGETGEIVWDKGRDFATVRKVLS
MPQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFDSPT
VAYSVLVVAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYK
EVKKDLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKYVNFLYL
ASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLD
KVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTS
TKEVLDATLIHQSITGLYETRIDLSQ |
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| PDB | 8kal Trans-nuclease activity of Cas9 activated by DNA or RNA target binding. |
| Resolution | 3.16 Å |
Binding residue
(original residue number in PDB) | K30 L35 K44 N46 G56 E57 T58 A59 T62 R63 K65 R66 R69 R70 R71 Y72 R74 R75 K76 N77 L101 S104 F105 K111 H116 V126 H129 T134 I135 H160 F164 R165 G166 Y325 H328 H329 K336 R340 F351 A360 I363 Q402 R403 T404 F405 N407 R447 I448 Y450 P454 L455 A456 R457 N459 S460 F462 R467 T472 I473 P475 K510 R661 H721 K742 Q894 P1090 Q1091 E1099 V1100 T1102 G1103 G1104 F1105 I1110 P1112 R1122 K1123 K1124 W1126 Y1131 E1225 L1226 A1227 P1229 Q1272 H1349 Q1350 Y1356 |
Binding residue
(residue number reindexed from 1) | K27 L32 K41 N43 G53 E54 T55 A56 T59 R60 K62 R63 R66 R67 R68 Y69 R71 R72 K73 N74 L98 S101 F102 K108 H113 V123 H126 T131 I132 H157 F161 R162 G163 Y322 H325 H326 K333 R337 F348 A357 I360 Q399 R400 T401 F402 N404 R444 I445 Y447 P451 L452 A453 R454 N456 S457 F459 R464 T469 I470 P472 K507 R658 H718 K739 Q881 P1052 Q1053 E1061 V1062 T1064 G1065 G1066 F1067 I1072 P1074 R1084 K1085 K1086 W1088 Y1093 E1187 L1188 A1189 P1191 Q1234 H1311 Q1312 Y1318 |
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