Structure of PDB 8g57 Chain G Binding Site BS01

Receptor Information

>8g57 Chain G (length=118) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTA
EILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPN
IQAVLLPKKTESHHKAKG

Ligand information

>8g57 Chain I (length=150) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tgcacaggatgtatatatctgacacgtgcctggagactagggagtaatcc
ccttggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggtg
ctagagctgtctacgaccaattgagcggcctcggcaccgggattctcgat

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8g57 Cryo-EM structure of the human Sirtuin 6-nucleosome complex.
Resolution	3.07 Å
Binding residue (original residue number in PDB)	A12 A14 K15 R17 R32 R77
Binding residue (residue number reindexed from 1)	A2 A4 K5 R7 R22 R67

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0030527	structural constituent of chromatin
GO:0031492	nucleosomal DNA binding
GO:0046982	protein heterodimerization activity

	Biological Process
GO:0006325	chromatin organization
GO:0008285	negative regulation of cell population proliferation
GO:0031507	heterochromatin formation
GO:0061644	protein localization to CENP-A containing chromatin

	Cellular Component
GO:0000786	nucleosome
GO:0005634	nucleus
GO:0005694	chromosome
GO:0043505	CENP-A containing nucleosome
GO:0070062	extracellular exosome

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External links

PDB	RCSB:8g57, PDBe:8g57, PDBj:8g57
PDBsum	8g57
PubMed	37058572
UniProt	P04908\|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)

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