Structure of PDB 8euy Chain G Binding Site BS01

Receptor Information

>8euy Chain G (length=164) Species: 4896 (Schizosaccharomyces pombe)

LKVPPAIAQFQKTLDKNTATQVFKLLNKYRPETAAEKKQRLVAEAEAVAN
GKVSKKPYNVKYGLNHVVALIEAKKAKLVLIASDVDPIELVVFLPALCKK
MGVPYAIVKNKARLGTVIHQKTAAVLAVTEVREEDKNELASIVSAVDANF
SAKYDESRRKWGGG

Ligand information

>8euy Chain 1 (length=1433)

uugaccucaaaucagguaggacuacgcgcugaacaauaagcgcaggaaaa
gaaaauaaccaugauucccucaguaacggagugaagcgggaaaagcucaa
auuugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaaga
agcugcuuugaguguagacgaucggucuaaguuccuuggaacaggacguc
agagagggugagaaccccgucuuuggucgauuggauaugccauauaaagc
gcuuucgaagagucgaguuguuugcagcucuaaaugggugguaucaucua
aagcuaaauauuggcgagagaccgauagcgaacaaguagagugaucgaaa
gaugaaaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaa
agggaagcauuggaaaucagucuuaccugggugagaucaguagucucucg
agacuaugcacucugaaccugugguaggucagcaucaguuuucgggggcg
gaaaaagaauaagggaagguggcguguuuauagccuuguuguaauacguc
cacuggggacugaggacugcggcuucgugccaaggaugcugacauaaugg
uuuucaauggcccgucuugaaacacggaccaaggagucuagcaucuaugc
gaguguuugggugaugaaaacccauccgcgaagugggaacgcccuugugg
cgugcaccagagcauagcuguugggacccgaaagauggugagaaccaucu
aguagcugguuccugccgaaguuuccggauagcagaaacucagaucaguu
uuaugaguauguaaaaugagaguuucuagugggccauuuuugguaagcag
aacuggcgaugcgggaugaaccgaacgugagguuaaggugccggaaugua
cgcucaucagacgaaaagguguuaguucaugaacuagcccugggcgcuua
agcguacuacccauaccucaccgucuggguuagcuuugagaagcucagac
gaguaggcaggcguggagguuugugacgaagccuugggcgugagccuggg
ucgaacagccucuagugcagaucuugguggaaguagcucuagcgaaacca
cagccuggggaacgggccaggucgucgcaaugguaauucaacuuaguacg
agaggaaccguugauucagaucauugguauuugcgcggagcuaucaucug
cuggauaacggcugaacgccucuaagccagaauccgugccagaaagcgac
gagguccgcauauguauaaaaauagagguaggcuacucuccuguaucgua
gaagaugggcgaugguugaugaaacggaaguguuuuauugacuuguccau
gaaauuccaugugcggaaucgaauccauugcauacgacuuuaauguggaa
cgggguauugagauucuuuguucccaagauuug

........................<<<<<<........>>>>>.>.....
....<<....>>..<<<<<......<<...>>.....>>>>>..<<<..<
<.......<<.<<<<<<<.......>>>>>>>.>>.......>>....<<
<<<.<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((.
.....<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>
>>>.>>........<<<<<<<..>>>>>>>.....<<<<<<..>>>>>>.
.>>>..................................<<....>>....
...........<<<<....>>>>...........................
.......<<<<<<<<<<<<.....<<<.<<<<.<<<.<<.<<<<<<<..>
>>>>>>>>...>>>..>>>>..>>>..<<<<<<<.<<<<<<<<<<<<<<<
.......<<<<<<<.......<..>........>>>>>>>......>>>>
>.>>>>>>>>>>........<<<.....>>>.....>>>>>>>....>>>
>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<
..<<<...<<<<.......>>>>...>>>...<<<....<<<....>>>.
....>>>....>>>>>>.>>>>>>..<<.<...<<<<<<....>>>>>>.
.....>.>>..<<<<<<....<.<<..>>.><<<<<<<<<<...<<<.<<
<<<<<....>>>>>>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>
>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<
<<<......<......<<<.<<<<<<<<..>>>>>>>>>>>.))).>...
.>>>>>>.>>>...>>>>>>><<<<<<<<<............>>>>>>>>
>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>
>...>>.>>>>>>>..>.....>>>>>><<.....<<....>>....>>.
...<<<<<........>>>>><<<<<<<..<<<<.<.<<<<<........
.........>>>>>.><<<<<...<<<<....<..>...>>>>..>>>>>
.<<<<....<<<<...........>>>>....>>>>.>>>>....>>>>>
>><.<<<<<<<....<<.......<<<<.<<.>>..>>>>....>>....
....<<<<<.....<<<<<<<<<<<......>>>>>>>>>>>...>>>>>
..........>>>>>>>.><<<<<<.....................<<<<
<<<...<<....>>..>>.>>>>>...>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8euy Chromatin localization of nucleophosmin organizes ribosome biogenesis.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): K105 R108 K127 K128 P129 K133 Y134 G135 L136 N137 H138 A141 L142 K147 V157 P159 L162 K183 Q192 K193 A196
• Binding residue (residue number reindexed from 1): K37 R40 K55 K56 P57 K61 Y62 G63 L64 N65 H66 A69 L70 K75 V85 P87 L90 K111 Q120 K121 A124

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000470 maturation of LSU-rRNA
• GO:0002181 cytoplasmic translation
• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8euy, PDBe:8euy, PDBj:8euy
• PDBsum: 8euy
• PubMed: 36423630
• UniProt: O13672|RL8_SCHPO Large ribosomal subunit protein eL8 (Gene Name=rpl8)