Structure of PDB 8dmk Chain G Binding Site BS01

Receptor Information
>8dmk Chain G (length=305) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDECTDEGGRPQRCMPEFVNAAFNVTVVATNTCGTPPEEYCVQTGVTGVT
KSCHLCDAGQPHLQHGAAFLTDYNNQADTTWWQSQTMLAGVQYPSSINLT
LHLGKAFDITYVRLKFHTSRPESFAIYKRTWEDGPWIPYQYYSGSCENTY
SKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDN
SPVLQEWVTATDISVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRC
KCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESA
SECLP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8dmk Chain G Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8dmk Cryo-EM reveals the molecular basis oflaminin polymerization and LN-lamininopathies.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		F105 L106 D108 T116 S278
Binding residue
(residue number reindexed from 1)		F69 L70 D72 T80 S242
Annotation score4
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:8dmk, PDBe:8dmk, PDBj:8dmk
PDBsum8dmk
PubMed36658135
UniProtP11047|LAMC1_HUMAN Laminin subunit gamma-1 (Gene Name=LAMC1)

[Back to BioLiP]