Structure of PDB 7zvw Chain G Binding Site BS01

Receptor Information
>7zvw Chain G (length=422) Species: 644223 (Komagataella phaffii GS115) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PQVYGADEINAVVLDASSYRTKIGYGSLDCPILNLPSYYGHQTKDGSEKF
IFEENSMLIPRPDYEIKKIMKDGIIDDFEGAVKQYNYMFDVLKLKPSEQP
ILVIESTQNEYEKKTALLKQLLKENKFVATFLIKNPTCVSFAHGRPNCLV
VDLGHDLVTITPILDGISLRKQVLGTHYAGAFLSQQLRQLLNHKGVEVVP
VYKVKSKVPTYFPDEAKFEERKYDFDISESFENFHKLRILREMKETLLQA
LPDSETEKLKEQETEEDTRYFEFPNGLNVPFTKYERVRLANSLFNPSEPY
TGESGPNIVVEGDKPRGLTSLVNQALNHLDVDLKPQLANNIILTGATSLI
PGVAERLNQELTAMNPGLKVRIHSSANVIERTCSAWIGGSILSSLGTFHQ
LWVSENEYDEVGAKKLIMDRFR
Ligand information
Ligand IDATP
InChIInChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyZKHQWZAMYRWXGA-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
FormulaC10 H16 N5 O13 P3
NameADENOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL14249
DrugBankDB00171
ZINCZINC000004261765
PDB chain7zvw Chain G Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7zvw The structure of the NuA4-Tip60 complex reveals the mechanism and importance of long-range chromatin modification.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		S21 S22 Y23 D156 G158 H159 R245 E249 A392 T393 L395
Binding residue
(residue number reindexed from 1)		S17 S18 Y19 D152 G154 H155 R241 E245 A346 T347 L349
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0005524 ATP binding
GO:0042393 histone binding
Biological Process
GO:0006281 DNA repair
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0051382 kinetochore assembly
Cellular Component
GO:0000785 chromatin
GO:0000812 Swr1 complex
GO:0005634 nucleus
GO:0016514 SWI/SNF complex
GO:0031011 Ino80 complex
GO:0035267 NuA4 histone acetyltransferase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7zvw, PDBe:7zvw, PDBj:7zvw
PDBsum7zvw
PubMed37550452
UniProtC4QXM9

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