Structure of PDB 7zci Chain G Binding Site BS01

Receptor Information
>7zci Chain G (length=905) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATIHVDGKEYEVNGADNLLEACLSLGLDIPYFCWHPALGSVGACRQCAVK
QYQNAEDTRGRLVMSCMTPASDGTFISIDDEEAKQFRESVVEWLMTNHPH
DCPVCEEGGNCHLQDMTVMTGHSFRRYRFTKRTHRNQDLGPFISHEMNRC
IACYRCVRYYKDYADGTDLGVYGAHDNVYFGRPEDGTLESEFSGNLVEIC
PTGVFTDKTHSERYNRKWDMQFAPSICQQCSIGCNISPGERYGELRRIEN
RYNGTVNHYFLCDRGRFGYGYVNLKDRPRQPVQRRGDDFITLNAEQAMQG
AADILRQSKKVIGIGSPRASVESNFALRELVGEENFYTGIAHGEQERLQL
ALKVLREGGIYTPALREIESYDAVLVLGEDVTQTGARVALAVRQAVKGKA
REMAAAQKVADWQIAAILNIGQRAKHPLFVTNVDDTRLDDIAAWTYRAPV
EDQARLGFAIAHALDNSAPAVDGIEPELQSKIDVIVQALAGAKKPLIISG
TNAGSLEVIQAAANVAKALKGRGADVGITMIARSVNSMGLGIMGGGSLEE
ALTELETGRADAVVVLENDLHRHASAIRVNAALAKAPLVMVVDHQRTAIM
ENAHLVLSAASFAESDGTVINNEGRAQRFFQVYDPAYYDSKTVMLESWRW
LHSLHSTLLSREVDWTQLDHVIDAVVAKIPELAGIKDAAPDATFRIRGQK
LAREPHRYSGRTAMRANISVHEPRQPQDIDTMFTFSMEGNNQPTAHRSQV
PFAWAPGWNSPQAWNKFQDEVGGKLRFGDPGVRLFETSENGLDYFTSVPA
RFQPQDGKWRIAPYYHLFGSDELSQRAPVFQSRMPQPYIKLNPADAAKLG
VNAGTRVSFSYDGNTVTLPVEIAEGLTAGQVGLPMGMSGIAPVLAGAHLE
DLKEA
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain7zci Chain G Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7zci A universal coupling mechanism of respiratory complex I.
Resolution2.69 Å
Binding residue
(original residue number in PDB)		H101 D104 C105 C108 G111 C114 Q117 T205 G206
Binding residue
(residue number reindexed from 1)		H98 D101 C102 C105 G108 C111 Q114 T202 G203
Annotation score1
Enzymatic activity
Enzyme Commision number 7.1.1.-
Gene Ontology
Molecular Function
GO:0003954 NADH dehydrogenase activity
GO:0005515 protein binding
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0043546 molybdopterin cofactor binding
GO:0046872 metal ion binding
GO:0048038 quinone binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0009060 aerobic respiration
GO:0022904 respiratory electron transport chain
GO:0042773 ATP synthesis coupled electron transport
GO:0045333 cellular respiration
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030964 NADH dehydrogenase complex
GO:0045271 respiratory chain complex I
GO:1990204 oxidoreductase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zci, PDBe:7zci, PDBj:7zci
PDBsum7zci
PubMed36104567
UniProtP33602|NUOG_ECOLI NADH-quinone oxidoreductase subunit G (Gene Name=nuoG)

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