Structure of PDB 7x74 Chain G Binding Site BS01

Receptor Information
>7x74 Chain G (length=131) Species: 100226 (Streptomyces coelicolor A3(2)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPVKGRATRQRAAVSAALQEVEEFRSAQELHDMLKHKGDAVGLTTVYRTL
QSLADAGEVDVLRTAEGESVYRRCSTGDHHHHLVCRACGKAVEVEGPAVE
KWAEAIAAEHGYVNVAHTVEIFGTCADCAGA
Ligand information
>7x74 Chain O (length=84) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
caaggcacatgacaacggtgttcagtgccgcgttgcccgataccccctac
ccgtagttgactggcatccgggcgccgggtcgcc
Receptor-Ligand Complex Structure
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PDB7x74 Structural basis of Streptomyces transcription activation by zinc uptake regulator.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		Q15 R16 T49 T50 R53
Binding residue
(residue number reindexed from 1)		Q10 R11 T44 T45 R48
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0001217 DNA-binding transcription repressor activity
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045892 negative regulation of DNA-templated transcription
GO:1900376 regulation of secondary metabolite biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032993 protein-DNA complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7x74, PDBe:7x74, PDBj:7x74
PDBsum7x74
PubMed35871291
UniProtQ9L2H5

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