Structure of PDB 7wl0 Chain G Binding Site BS01

Receptor Information
>7wl0 Chain G (length=219) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QQLQKEEEARKVKSGIRQMRLFSQDECAKIEARIDEVVSRAEKGLYNEHT
VDRAPLRNKYFFGEGYTYGAQLQKRGPGQERLYPPGDVDEIPEWVHQLVI
QKLVEHRVIPEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSD
SALCFGCKFQFKPIRVSEPVLSLPVRRGSVTVLSGYAADEITHCIRPQDI
KERRAVIILRKTRLDAPRL
Ligand information
Receptor-Ligand Complex Structure
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PDB7wl0 Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		P128 L129 R130 Y139 Y141 G142 I201 V202 S203 H204 V205 P207 F234 I237 T265
Binding residue
(residue number reindexed from 1)		P55 L56 R57 Y66 Y68 G69 I128 V129 S130 H131 V132 P134 F161 I164 T192
Enzymatic activity
Enzyme Commision number 1.14.11.53: mRNA N(6)-methyladenine demethylase.
Gene Ontology
Molecular Function
GO:0035515 oxidative RNA demethylase activity
Biological Process
GO:0006397 mRNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:7wl0, PDBe:7wl0, PDBj:7wl0
PDBsum7wl0
PubMed35333330
UniProtQ6P6C2|ALKB5_HUMAN RNA demethylase ALKBH5 (Gene Name=ALKBH5)

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