Structure of PDB 7td5 Chain G Binding Site BS01
Receptor Information
>7td5 Chain G (length=372) Species:
9606
(Homo sapiens) [
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SWSHPQFEKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGS
NRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGS
RGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLW
NIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSK
RMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDL
ILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRF
SMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSF
SRDSSILIAVCDDASIWRWDRL
Ligand information
>7td5 Chain J (length=10) Species:
9606
(Homo sapiens) [
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TKAARKSAPA
Receptor-Ligand Complex Structure
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PDB
7td5
CK2-mediated phosphorylation of SUZ12 promotes PRC2 function by stabilizing enzyme active site.
Resolution
2.994 Å
Binding residue
(original residue number in PDB)
F97 Y148 Y308 I363 W364 Y365 R414
Binding residue
(residue number reindexed from 1)
F29 Y80 Y240 I295 W296 Y297 R346
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:7td5
,
PDBe:7td5
,
PDBj:7td5
PDBsum
7td5
PubMed
36351927
UniProt
O75530
|EED_HUMAN Polycomb protein EED (Gene Name=EED)
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