Structure of PDB 7t2d Chain G Binding Site BS01

Receptor Information
>7t2d Chain G (length=168) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATPENYLFQGRQECYAFNGTQRFLERYIYNREEFARFDSDVGEFRAVTEL
GRPAAEYWNSQKDILEEKRAVPDRMCRHNYELGGPMTLQRRVQPRVNVSP
SNLLVCHVTDFYPGSIQVRFLNGQEETAGVVSTNLIRNGDWTFQILVMLE
MTTCQVEHTSLDSPVTVE
Ligand information
>7t2d Chain H (length=14) Species: 1313 (Streptococcus pneumoniae) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ATGLAWEWWRTVYE
Receptor-Ligand Complex Structure
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PDB7t2d CD4 + T cell-mediated recognition of a conserved cholesterol-dependent cytolysin epitope generates broad antibacterial immunity.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		G11 Q13 E28 Y30 Y60 W61 I67 E70 K71 V74 R77 M78 H81 N82 L85
Binding residue
(residue number reindexed from 1)		G10 Q12 E25 Y27 Y57 W58 I64 E67 K68 V71 R74 M75 H78 N79 L82
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0016020 membrane
GO:0042613 MHC class II protein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:7t2d, PDBe:7t2d, PDBj:7t2d
PDBsum7t2d
PubMed37100059
UniProtP04440|DPB1_HUMAN HLA class II histocompatibility antigen, DP beta 1 chain (Gene Name=HLA-DPB1)

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