Structure of PDB 7pnx Chain G Binding Site BS01

Receptor Information

>7pnx Chain G (length=327) Species: 9606 (Homo sapiens)

AFVIPKKNVPTSKRETYTEDFIKKQIEEFNIGKRHLANMMGEDPETFTQE
DIDRAIAYLFPSGLFEKRARPVMKHPEQIFPRQRAIQWGEDGRPFHYLFY
TGKQSYYSLMHDVYGMLLNLEKHQVIGSRWLIKEELEEMLVEKLSDLDYM
QFIRLLEKLLTSQCGAAEEEFVQRFRRSVTLESKKQLIEPVQYDEQGMAF
SKSEGKRKTAKAEAIVYKHGSGRIKVNGIDYQLYFPITQDREQLMFPFHF
VDRLGKHDVTCTVSGGGRSAQAGAIRLAMAKALCSFVTEDEVEWMRQAGL
LTTDPRVRERKKPGQEGARRKFTWKKR

Ligand information

>7pnx Chain A (length=951)

aauagguuugguccuagccuuucuauuagcucuuaguaagauuacacaug
caagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaa
gggacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagc
cacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaag
uuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccac
cgcggucacacgauuaacccaagucaauagaagccggcguaaagaguguu
uuagaucacccccuccccaauaaagcuaaaacucaccugaguuguaaaaa
acuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaa
cacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuag
cccuaaaccucaacaguuaaaucaacaaaacugcucgccagaacacuacg
agccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuag
aggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuug
cucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaag
uaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugag
guggcaagaaaugggcuacauuuucuaccccagaaaacuacgauagcccu
uaugaaacuuaagggucgaagguggauuuagcaguaaacugagaguagag
ugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuc
cucaaguauacuucaaaggacauuuaacuaaaaccccuacgcauuuauau
agaggagacaagucguaacaugguaaguguacuggaaagugcacuuggac
g

...((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<....<<<.<<
<..<......>......<<.......<<<<.<..<<<.....>>>.>..>
>>>..<<<<....<<...<<<....>>>..>>......>>>>.<<...>>
.>>.<<<....>>>.....>>>>>>.........<<<....<<<<....>
>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>
>)).......)))..>>>>>..>>.>>>>>>....<<<((.....<<<<.
.<<<<...............<<<<<<......<<<.<<<.<<<......>
>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>..
.>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>
>..........<.<<<<<......))..>>>>>.>.>>>.<<.......<
<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<
<..<<<<<<<<<<.....<<........>>..........<<<<<<<...
....<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>
>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>
>>>>..>>.>>>>>>>>.....<<<<.....>>>>.....<....<<<<<
<<.......>>>>>>>....>.....>>>>>.....<<<<<<<.......
..>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<
<<<..<<<<<......<<<....<<.....>>...>>>.......>>>>>
.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>....
.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7pnx Mechanism of mitoribosomal small subunit biogenesis and preinitiation.
• Resolution: 2.76 Å
• Binding residue (original residue number in PDB): F117 E118 R120 L216 D217 Q220 R276 K277 T278 I306 G336 R337 S338 A339 R375 V376 R377 E378 R379 K380 K381 P382 G383 R388 R389 K390 T392 W393 K394 K395
• Binding residue (residue number reindexed from 1): F65 E66 R68 L147 D148 Q151 R207 K208 T209 I237 G267 R268 S269 A270 R306 V307 R308 E309 R310 K311 K312 P313 G314 R319 R320 K321 T323 W324 K325 K326

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005730 nucleolus
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7pnx, PDBe:7pnx, PDBj:7pnx
• PDBsum: 7pnx
• PubMed: 35676484
• UniProt: P82933|RT09_HUMAN Small ribosomal subunit protein uS9m (Gene Name=MRPS9)