Structure of PDB 7lo0 Chain G Binding Site BS01

Receptor Information

>7lo0 Chain G (length=154) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MAKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIYVGSAES
EEYDQVLDSVLVGPVPAGRHMFVFQADAPNPGLIPDADAVGVTVVLITCT
YRGQEFIRVGYYVNNEYTETELRENPPVKPDFSKLQRNILASNPRVTRFH
INWE

Ligand information

>7lo0 Chain O (length=14) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

DPRRQELLEARFTG

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7lo0 Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.
Resolution	2.71 Å
Binding residue (original residue number in PDB)	V45 A48 E51 D54 V94 L96 R108 G110 Y112 R145
Binding residue (residue number reindexed from 1)	V45 A48 E51 D54 V94 L96 R108 G110 Y112 R145

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Biological Process
GO:0006325	chromatin organization

	Cellular Component
GO:0005634	nucleus

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Biological Process

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Cellular Component

External links

PDB	RCSB:7lo0, PDBe:7lo0, PDBj:7lo0
PDBsum	7lo0
PubMed	35136069
UniProt	Q9Y294\|ASF1A_HUMAN Histone chaperone ASF1A (Gene Name=ASF1A)

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