Structure of PDB 7kzs Chain G Binding Site BS01

Receptor Information
>7kzs Chain G (length=577) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CLDLWREKNDRLVRQAKVAQNSGLTLRRQQLAQDALEGLRGLLHSLQGLP
AAVPVLPLELTVTCNFIILRASLAQGFTEDQAQDIQRSLERVLETQEEQG
LRELWDSVLRASCLLPELLSALHRLVGLQAALWLSADRLGDLALLLETLN
GSQSGASKDLLLLLKTWSPPAEELDAPLTLQDAQGLKDVLLTAFAYRQGL
QELITGNPDKALSSLHEAASGLCPRPVLVQVYTALGSCHRKMGNPQRALL
YLVAALKEGSAWGPPLLEASRLYQQLGDTTAELESLELLVEALNVPAPQF
LIEVELLLPPPDLASPLHCGTQSQTKHILASRCLQTGRAGDAAEHYLDLL
ALLLDSSEPRFSPPPSPPGPCMPEVFLEAAVALIQAGRAQDALTLCEELL
SRTSSLLPKMSRLWEDELPYCPLWVSATHLLQGQAWVQLGAQKVAISEFS
RCLELLFRATPEEKEQGAAFNCEQGCKSDAALQQLRAAALISRGLEWVAS
GQDTKALQDFLLSVQMCPGNRDTYFHLLQTLKRLDRRDEATALWWRLEAQ
TLWSLPLYLESYLSWIRPSDRDAFLEE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7kzs Chain G Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7kzs Structure of the FA core ubiquitin ligase closing the ID clamp on DNA.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		C392 E395 C499 C503
Binding residue
(residue number reindexed from 1)		C371 E374 C472 C476
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0005515 protein binding
Biological Process
GO:0001541 ovarian follicle development
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0007005 mitochondrion organization
GO:0007286 spermatid development
GO:0009314 response to radiation
GO:0036297 interstrand cross-link repair
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0043240 Fanconi anaemia nuclear complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7kzs, PDBe:7kzs, PDBj:7kzs
PDBsum7kzs
PubMed33686268
UniProtO15287|FANCG_HUMAN Fanconi anemia group G protein (Gene Name=FANCG)

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