Structure of PDB 7kmf Chain G Binding Site BS01

Receptor Information
>7kmf Chain G (length=287) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRIQGLRANLTSAIETLC
GVDSSVAVSSGGELFLRFISLASLEYSDYSKCKKIMIERGELFLRRISLS
RNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQP
DLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGII
NKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKALKE
EHPWVDYTAPSLITLLFTDLGVLTPSAVSDELIKLYL
Ligand information
Ligand IDF6P
InChIInChI=1S/C6H13O9P/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13/h3-5,7-10H,1-2H2,(H2,11,12,13)/t3-,4-,5+,6-/m1/s1
InChIKeyBGWGXPAPYGQALX-ARQDHWQXSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=P(O)(O)OCC1OC(O)(CO)C(O)C1O
OpenEye OEToolkits 1.5.0C(C1C(C(C(O1)(CO)O)O)O)OP(=O)(O)O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@](O1)(CO)O)O)O)OP(=O)(O)O
CACTVS 3.341OC[C]1(O)O[CH](CO[P](O)(O)=O)[CH](O)[CH]1O
CACTVS 3.341OC[C@@]1(O)O[C@H](CO[P](O)(O)=O)[C@@H](O)[C@@H]1O
FormulaC6 H13 O9 P
Name6-O-phosphono-beta-D-fructofuranose;
FRUCTOSE-6-PHOSPHATE;
6-O-phosphono-beta-D-fructose;
6-O-phosphono-D-fructose;
6-O-phosphono-fructose
ChEMBLCHEMBL604196
DrugBank
ZINCZINC000004096690
PDB chain7kmf Chain G Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7kmf Sugar phosphate activation of the stress sensor eIF2B.
Resolution2.91 Å
Binding residue
(original residue number in PDB)		Y130 S131 R132 G196 E198 N208 K209
Binding residue
(residue number reindexed from 1)		Y123 S124 R125 G189 E191 N201 K202
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003743 translation initiation factor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0002183 cytoplasmic translational initiation
GO:0006412 translation
GO:0006413 translational initiation
GO:0009408 response to heat
GO:0009749 response to glucose
GO:0014003 oligodendrocyte development
GO:0043434 response to peptide hormone
GO:0044237 cellular metabolic process
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005851 eukaryotic translation initiation factor 2B complex
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7kmf, PDBe:7kmf, PDBj:7kmf
PDBsum7kmf
PubMed34103529
UniProtQ14232|EI2BA_HUMAN Translation initiation factor eIF2B subunit alpha (Gene Name=EIF2B1)

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