Structure of PDB 7bgb Chain G Binding Site BS01

Receptor Information
>7bgb Chain G (length=339) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DTSQWPLLLKNFDKLNVRTTHYTPLACGSNPLKREIGDYIRTGFINLDKP
SNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQ
SAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPRQLRVRTIYESK
MIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGV
MSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKD
SAVNAICYGAKIMLPGVLRYEDGIEVNQEIVVITTKGEAICMAIALMTTA
VISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKLM
Ligand information
>7bgb Chain B (length=92) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccugcggcggccgcaggaagaggaacggagcgaguccccgcggcgcgauu
cccugagcugugggacgugcacccaggacucggcucacacau
<<<<<<<<.>>>>>>>>..........<<<<<<<<<<.....<<<<<...
<<<........>>>.>>>>>.....>>>>>>.>>>>......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7bgb Structure of human telomerase holoenzyme with bound telomeric DNA.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		R141 V143 K144 A305 A313 K314 M316 G319 H360 I366 R368 V369 W380 G381 L382 K385
Binding residue
(residue number reindexed from 1)		R94 V96 K97 A252 A260 K261 M263 G266 H307 I313 R315 V316 W327 G328 L329 K332
Enzymatic activity
Catalytic site (original residue number in PDB) D125 Y153 R227
Catalytic site (residue number reindexed from 1) D78 Y106 R174
Enzyme Commision number 5.4.99.-
Gene Ontology
Molecular Function
GO:0003720 telomerase activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0009982 pseudouridine synthase activity
GO:0016853 isomerase activity
GO:0034513 box H/ACA snoRNA binding
GO:0070034 telomerase RNA binding
Biological Process
GO:0000455 enzyme-directed rRNA pseudouridine synthesis
GO:0000495 box H/ACA sno(s)RNA 3'-end processing
GO:0001522 pseudouridine synthesis
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0007004 telomere maintenance via telomerase
GO:0009451 RNA modification
GO:0031118 rRNA pseudouridine synthesis
GO:0031120 snRNA pseudouridine synthesis
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0033979 box H/ACA sno(s)RNA metabolic process
GO:0042254 ribosome biogenesis
GO:0090666 scaRNA localization to Cajal body
GO:0090669 telomerase RNA stabilization
GO:1904867 protein localization to Cajal body
GO:1904872 regulation of telomerase RNA localization to Cajal body
GO:1904874 positive regulation of telomerase RNA localization to Cajal body
GO:1990481 mRNA pseudouridine synthesis
Cellular Component
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005697 telomerase holoenzyme complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0015030 Cajal body
GO:0031429 box H/ACA snoRNP complex
GO:0072589 box H/ACA scaRNP complex
GO:0090661 box H/ACA telomerase RNP complex
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7bgb, PDBe:7bgb, PDBj:7bgb
PDBsum7bgb
PubMed33883742
UniProtO60832|DKC1_HUMAN H/ACA ribonucleoprotein complex subunit DKC1 (Gene Name=DKC1)

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