Structure of PDB 6zww Chain G Binding Site BS01

Receptor Information

>6zww Chain G (length=735) Species: 562 (Escherichia coli)

LTFTALQQRLDSLMLRDRLRFSRRLHGVKPDAQQAIFQEMAKEIDQAAGK
VLLREAARPEITYPDNLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQL
PKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGGCIGYKVRF
SDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLL
GYLKELLPRRPDLKIIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRY
RPIVEDTERDQLQAIFDAVDELSQESHGDILIFMSGEREIRDTADALNKL
NLRHTEILPLYARLSNSEQNRVFQSHSGRRIVLATNVAETSLTVPGIKYV
IDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYS
EDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQ
DGVRLLEELGAITTDYKLTPLGRQLSQLPVDPRLARMVLEAQKHGCVREA
MIITSALSIQDPRERPMDKQQASDEKHRRFHDKESDFLAFVNLWNYLGEQ
QKALSSNAFRRLCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAE
YREIHIALLTGLLSHIGMKDADKQEYTGARNARFSIFPGSGLFKKPPKWV
MVAELVETSRLWGRIAARIDPEWVEPVAQHLIKRTYSEPHWERAQGAVMA
TEKVTVYGLPIVAARKVNYSQIDPALCRELFIRHA

Ligand information

>6zww Chain H (length=10)

uuuuuuuuuu

..........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zww Large-scale ratcheting in a bacterial DEAH/RHA-type RNA helicase that modulates antibiotics susceptibility.
• Resolution: 3.16 Å
• Binding residue (original residue number in PDB): R131 R132 R159 T174 G176 A180 G299 E300 A325 R326 T348 N349 V350 S354 R370 Q495 P497 V498 Q600 F655 F661 T676 R678 R682
• Binding residue (residue number reindexed from 1): R121 R122 R149 T164 G166 A170 G286 E287 A312 R313 T335 N336 V337 S341 R357 Q477 P479 V480 Q582 F637 F643 T658 R660 R664

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003724 RNA helicase activity
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity

External links

• PDB: RCSB:6zww, PDBe:6zww, PDBj:6zww
• PDBsum: 6zww
• PubMed: 34290142
• UniProt: P43329|HRPA_ECOLI ATP-dependent RNA helicase HrpA (Gene Name=hrpA)