Structure of PDB 6w89 Chain G Binding Site BS01

Receptor Information
>6w89 Chain G (length=284) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQ
GKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTG
RLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPV
MIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFS
KVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVS
NMSHLARQRLLGRSWSVPVIRHLFAPLKEYFACV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6w89 Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation.
Resolution2.499 Å
Binding residue
(original residue number in PDB)		I715 V716 R720 V763 N838 S881 L883
Binding residue
(residue number reindexed from 1)		I87 V88 R92 V135 N210 S253 L255
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6w89, PDBe:6w89, PDBj:6w89
PDBsum6w89
PubMed32385248
UniProtQ9Y6K1|DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (Gene Name=DNMT3A)

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