Structure of PDB 6s0x Chain G Binding Site BS01

Receptor Information
>6s0x Chain G (length=173) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRVGKKIIDIPSDVTVTFDGNHVTVKGPKGELSRTLNERMTFKQEENTIE
VVRPSDSKEDRTNHGTTRALLNNMVQGVSQGYVKVLELVGVGYRAQMQGK
DLILNVGYSHPVEIKAEENITFSVEKNTVVKVEGISKEQVGALASNIRSV
RPPEPYKGKGIRYQGEYVRRKEG
Ligand information
>6s0x Chain A (length=2905) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgauga
aggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuuga
uccagagauuuccgaauggggaaacccagcaugaguuaugucauguuauc
gauaugugaauacauagcauaucagaaggcacacccggagaacugaaaca
ucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggc
gagcgaaaugggaagagcccaaaccaacaagcuugcuuguugggguugua
ggacacucuacggaguuacaaaggacgacauuagacgaaucaucuggaaa
gaugaaucaaagaagguaauaauccuguagucgaaaauguugucucucuu
gaguggauccugaguacgacggagcacgugaaauuccgucggaaucuggg
aggaccaucuccuaaggcuaaauacucucuagugaccgauagugaaccag
uaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaac
cugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggcg
ugccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagc
aguaaauguggagccguagcgaaagcgagucugaauagggcguuuaguau
uuggucguagacccgaaaccaggugaucuacccuuggucagguugaaguu
cagguaacacugaauggaggaccgaaccgacuuacguugaaaagugagcg
gaugaacugaggguagcggagaaauuccaaucgaaccuggagauagcugg
uucucuccgaaauagcuuuagggcuagccucaagugaugauuauuggagg
uagagcacuguuuggacgaggggccgguuaccgaauucagacaaacuccg
aaugccaauuaauuuaacuugggagucagaacaugggugauaagguccgu
guucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauaug
uuaaguggaaaaggauguggcguugcccagacaacuaggauguuggcuua
gaagcagccaucauuuaaagagugcguaauagcucacuagucgagugaca
cugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggauug
uccuuuggacaaugguaggagagcguucuaagggcguugaagcaugaucg
uaaggacauguggagcgcuuagaagugagaaugccggugugaguagcgaa
agacgggugagaaucccguccaccgauugacuaagguuuccagaggaagg
cucguccgcucuggguuagucggguccuaagcugaggccgacaggcguag
gcgauggauaacagguugauauuccuguaccaccuauaaucguuuuaauc
gauggggggacgcaguaggauaggcgaagcgugcgauuggauugcacguc
uaagcaguaaggcugaguauuaggcaaauccgguacucguuaaggcugag
cugugauggggagaagacauugugucuucgagucguugauuucacacugc
cgagaaaagccucuagauagaaaauaggugcccguaccgcaaaccgacac
agguagucaagaugagaauucuaaggugagcgagcgaacucucguuaagg
aacucggcaaaaugaccccguaacuucgggagaaggggugcucuuuaggg
uuaacgcccagaagagccgcagugaauaggcccaagcgacuguuuaucaa
aaacacaggucucugcuaaaccguaaggugauguauaggggcugacgccu
gcccggugcuggaagguuaagaggagugguuagcuucugcgaagcuacga
aucgaagccccaguaaacggcggccguauaacgguccuaagguagcgaaa
uuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggc
acugucucaacgagagacucggugaaaucauaguaccugugaagaugcag
guuacccgcgacaggacggaaagaccccguggagcuuuacuguagccuga
uauugaaauucggcacagcuuguacaggauagguaggagccuuugaaacg
ugagcgcuagcuuacguggaggcgcuggugggauacuacccuagcugugu
uggcuuucuaacccgcaccacuuaucguggugggagacagugucaggcgg
gcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcucaaa
gguucccucagaaugguuggaaaucauucauagaguguaaaggcauaagg
gagcuugacugcgagaccuacaagucgagcagggucgaaagacggacuua
gugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcu
accccggggauaacaggcuuaucucccccaagaguucacaucgacgggga
gguuuggcaccucgaugucggcucaucgcauccuggggcuguagucgguc
ccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucag
aacgucgugagacaguucggucccuauccgucgugggcguaggaaauuug
agaggagcuguccuuaguacgagaggaccgggauggacauaccucuggug
uaccaguugucgugccaacggcauagcuggguagcuauguguggacggga
uaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucc
caacuucgguuauaagaucccucaaagaugaugagguuaauagguucgag
guggaagcauggugacauguggagcugacgaauacuaaucgaucgaagac
uuaau
<<<<<<......<<<<<<<<<<<....[.....[<<<<<<.[..<.....
.<<<.<<.[...((.>>......<<<<<<<..<<.))...]..>>.....
>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<
<<<<<.............>>>>>.>>.>.....<<<<<......<.....
.>.......>>>>.>.........<<....>>...<<<<......<<...
..>>.....>>>>...<<.....<<<<<<<<....>>>>>>>>......<
<<<<<<...........................<<<....<<<<......
>>>>.........<<<.......>>>...>>>..................
..>>>..>>>>......<..<<<..........>>>..>........<<<
<<..<<<<>>>>>...>>.......]..>>>>>>.]..............
..<<....>>................<<<....>>>..............
]....>>>>>>>>>>>..<....<<<...<<..........>>...>>>.
....<........>...<<<<.<....<<<<<<..<<<<...<.<...<<
<.....>>>...>.>...<<....>>..<<<<.....>>>>......>>>
>..>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<
<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>
>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>
...<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<....
<.......<<<<<<<<...<<.........>>...>>>>>>>>.......
.>..>.>>.>>>>...>>>>>>>.>>...<<<<.<<<<......>>>>.>
>>>.....<<<......>>>...<<<<..<<...<<<........<<<<<
<...........<<....<...<<<........<<.....<...<<<...
......>>>...>..........................>>....>>>..
.>...>>...................>>>>>>.>>>...>>.>>>>.<<<
<.......>>>>.....>>>>>...<<.<<<<.<.......<<<<<.<..
....>.>>>>>....>.>>>>>>.........>.>>>>.......<....
.<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<.<<...<<
.....>>.>>.>>>....((<<<<.<<...<<<...<<<....>>>...>
>>...>>...<<<<<........>>>>>))<<<<<<<...........<<
...<<<<....<<<<..<<<...<....<.<<....{.{....>>.>.<<
...<<<<...<<<.<<<<<<..<<.....>>.>>>>>>......>>>...
>>>>....>>..........................>...>>>...>>>>
.........>>>>..>>......>>>>>>>>>>>.>>>.....<<.....
.>>>>>>>.<<<<....>.>>>..>>>>...<<<.....<.<..<..<<.
........<.....<<<<<....<....>.....>>>>><<<<<<<.<<.
.......>>.>>>>>>>............<<<<<<<<<..<<<.......
..>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.
<<<..<<<<<<<...<<...<<...<<<<<.............>>>>>..
.>>...>>.>>>>>..>>>>>.<<<<.....>>>>.........<.....
......<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>
..>..>>.>..>.>...>>>..>...........<<<............>
>>>.<<<<<<<<.[[..[[......<<<..[[<<<<..<<<<<.<<<<<<
<<<.<<<<.<<<<....<<...............<<..............
.<<........>>......................>>......>>..>..
>>>.>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..
>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...
<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>
>>>>>....<<....<<......>>....>>..<<<....>>>.>>)))]
......<<<<<<.<<<..>>>>..>>>>>>>>>.............>>>>
..]].>>>........<<<.<.<<<<<<...<<.......>>...>>>>>
>...>>>>.........<<<<<.<..<<<..<<<<<<<<<......>>>>
>>..>>>.<<<<<.....>>>>>.....>>>....>...>>>.>>....<
<<<<<<....>>>.>>>>....]]...]]>>>>>>>>......<<<<<..
.<.<<...<<<<<<...............>>>>>>..<<<<<...<<<<.
..<<<<<<<<<<<.}.}>>>>>>..>>>>>...>>>>.>>>>>...<<<.
...<<<<<...........>>>>>....>>>.>>.>.......>>>>>..
...............<<<<<<<<<.......>>>>>....<<<<<<<<.<
<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>
>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6s0x Exit tunnel modulation as resistance mechanism of S. aureus erythromycin resistant mutant.
Resolution2.425 Å
Binding residue
(original residue number in PDB)		R3 V4 R62 T63 G66 T67 A70 N74 G108 Y109 S110 H111 K138 G142 S146 E155 Y157 K160
Binding residue
(residue number reindexed from 1)		R2 V3 R61 T62 G65 T66 A69 N73 G107 Y108 S109 H110 K137 G141 S145 E154 Y156 K159
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6s0x, PDBe:6s0x, PDBj:6s0x
PDBsum6s0x
PubMed31391518
UniProtW8U3X2

[Back to BioLiP]