Structure of PDB 6pzv Chain G Binding Site BS01
Receptor Information
>6pzv Chain G (length=242) Species:
9913
(Bos taurus) [
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SPKCTECLQYLDDPELRYEQHPPDAVEEIQILTNERLSIFDANESGFESY
EDLPQHKLTCFSVYCKRGHLCPIDTGLIEKDVELLFSGSAKPIYEDDPSP
EGGINGKNFGPINEWWIAGFDGGEKALLGFSTSFAEYILMDPSPEYAPLF
SVMQEKIYISKIVVEFLQSNPDSTYEDLINKIETTVPPCMLNLNRFTEDS
LLRHAQFVVEQVESYDRAGDSDEQPIFLSPCMRDLIKLAGVT
Ligand information
>6pzv Chain H (length=19) Species:
9606
(Homo sapiens) [
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RTKQTARKSTGGKAPRCQL
Receptor-Ligand Complex Structure
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PDB
6pzv
Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation.
Resolution
3.01 Å
Binding residue
(original residue number in PDB)
I425 E426 D428 I459 N460 E461 W462 W463 I464 F467 E483 Q558 S561 Y562 D567 E570
Binding residue
(residue number reindexed from 1)
I78 E79 D81 I112 N113 E114 W115 W116 I117 F120 E136 Q211 S214 Y215 D220 E223
Enzymatic activity
Enzyme Commision number
2.1.1.37
: DNA (cytosine-5-)-methyltransferase.
External links
PDB
RCSB:6pzv
,
PDBe:6pzv
,
PDBj:6pzv
PDBsum
6pzv
PubMed
32675241
UniProt
Q24K09
|DNMT1_BOVIN DNA (cytosine-5)-methyltransferase 1 (Gene Name=DNMT1)
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