Structure of PDB 6lwn Chain G Binding Site BS01

Receptor Information
>6lwn Chain G (length=237) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEGPELHLASQFVNEACRCVEKSSVSRNPEVPFESASARGKELRLILSPP
QQEPLALVFRFGMSGSFQLVPREELPRHAHLRFYTAPALCFVDIRRFGRW
DLGGKWQPGRGPCVLQEYQQFRENVLRNLADKAFDRPICEALLDQRFFNG
IGNYLRAEILYRLKIPPFEKARSVLEALPDLLELCHSVPKEVVQLSPEED
FAAFRAWLRCYGMPGMSSLQDRHGRTIWFQGDPGPLA
Ligand information
Receptor-Ligand Complex Structure
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PDB6lwn DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes.
Resolution2.74 Å
Binding residue
(original residue number in PDB)		P2 E3 K54 R78 G80 M81 R118 F120 Q130 R133 Q168 N176 Y263 R277
Binding residue
(residue number reindexed from 1)		P1 E2 K41 R60 G62 M63 R95 F97 Q107 R110 Q145 N153 Y211 R225
Enzymatic activity
Enzyme Commision number 3.2.2.-
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270 zinc ion binding
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
Biological Process
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6lwn, PDBe:6lwn, PDBj:6lwn
PDBsum6lwn
PubMed34226550
UniProtQ96FI4|NEIL1_HUMAN Endonuclease 8-like 1 (Gene Name=NEIL1)

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