Structure of PDB 6lrt Chain G Binding Site BS01

Receptor Information

>6lrt Chain G (length=423) Species: 324602 (Chloroflexus aurantiacus J-10-fl) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MDRAAQIKQIADSWNTPRFAGIVRPYTPEDVYRLRGSVQIEYTLARMGAE
RLWNLLHTEPYINALGALTGNQAMQQVKAGLKAIYLSGWQVAADANLAGQ
MYPDQSLYPANSGPQLVRNINNALRRADQIYHSEGRNDIYWFAPIVADAE
AGFGGPLNVFEIMKAYIEAGAAGVHFEDQLASEKKCGHMGGKVLIPTQAA
IRNLVAARLAADVMGVPTIIVARTDANAATLLTSDIDERDRPFCTGERTS
EGFYRVRAGLDQAIARGLAYAPYADMIWCETSEPNLEEARRFAEAIHAQF
PGKLLAYNCSPSFNWKKKLDDATIAAFQRELGAMGYKFQFVTLAGFHALN
YSMFELARNYRDRGMAAYSELQQAEFAAEAYGYTATRHQREVGTGYFDEV
AQVIAGGEISTTALTGSTEEEQF

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

6lrt Chain G Residue 504 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6lrt Structural studies reveal the molecular mechanism of isocitrate lyase from Chloroflexus aurantiacus
Resolution	2.9 Å
Binding residue (original residue number in PDB)	D104 D148 K184
Binding residue (residue number reindexed from 1)	D104 D148 K184
Annotation score	1

Enzymatic activity

Enzyme Commision number

4.1.3.1: isocitrate lyase.

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity
GO:0004451	isocitrate lyase activity
GO:0016829	lyase activity
GO:0046872	metal ion binding

	Biological Process
GO:0019752	carboxylic acid metabolic process

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Molecular Function

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Biological Process

External links

PDB	RCSB:6lrt, PDBe:6lrt, PDBj:6lrt
PDBsum	6lrt
PubMed
UniProt	A9WDE7

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