Structure of PDB 6jpw Chain G Binding Site BS01

Receptor Information

>6jpw Chain G (length=38) Species: 64320 (Zika virus)

DMYIERAGDITWEKDAEVTGNSPRLDVALDESGDFSLV

Ligand information

>6jpw Chain L (length=5) Species: 32630 (synthetic construct)

SGKRK

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6jpw Biocompatible Macrocyclization between Cysteine and 2-Cyanopyridine Generates Stable Peptide Inhibitors.
• Resolution: 1.951 Å
• Binding residue (original residue number in PDB): G82 D83 F84 L86
• Binding residue (residue number reindexed from 1): G33 D34 F35 L37

Enzymatic activity

• Enzyme Commision number: 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
  2.1.1.57: methyltransferase cap1.
  2.7.7.48: RNA-directed RNA polymerase.
  3.4.21.91: flavivirin.
  3.6.1.15: nucleoside-triphosphate phosphatase.
  3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity

Cellular Component

• GO:0044423 virion component

External links

• PDB: RCSB:6jpw, PDBe:6jpw, PDBj:6jpw
• PDBsum: 6jpw
• PubMed: 31188009
• UniProt: Q32ZE1|POLG_ZIKV Genome polyprotein