Structure of PDB 5zoo Chain G Binding Site BS01
Receptor Information
>5zoo Chain G (length=387) Species:
9606
(Homo sapiens) [
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FTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECI
RGRKATLEELQTVHSEAHTLLYGTNPLSVFVRLPCGGVGVDSDTIWNEVH
SAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFN
SVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYD
DGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVM
PIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGG
RIVLALEGGYDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRS
MEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEA
Ligand information
>5zoo Chain A (length=14) Species:
9606
(Homo sapiens) [
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HIRGSITQGIPRSY
Receptor-Ligand Complex Structure
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PDB
5zoo
Structural basis of the specific interaction of SMRT corepressor with histone deacetylase 4.
Resolution
1.85 Å
Binding residue
(original residue number in PDB)
D759 M810 F812 G868 F870 F871 P872 P942
Binding residue
(residue number reindexed from 1)
D93 M144 F146 G202 F204 F205 P206 P276
Enzymatic activity
Enzyme Commision number
3.5.1.98
: histone deacetylase.
External links
PDB
RCSB:5zoo
,
PDBe:5zoo
,
PDBj:5zoo
PDBsum
5zoo
PubMed
30321390
UniProt
P56524
|HDAC4_HUMAN Histone deacetylase 4 (Gene Name=HDAC4)
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