Structure of PDB 5nrl Chain G Binding Site BS01

Receptor Information
>5nrl Chain G (length=372) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKFQGHGLKTELHSALKSSNLNLIRRTYQTGENPYLSNRRYERGLKFKRI
AQERTLQKQQEEEELKRKLKQEEDEKDKRKLIESGDPNLELHEDKFLLDL
SKFKIYYDNNHGYEWWDTAYHPSIRYVAHPLPEKAKVSIKAYLTQHERKR
LRRNRRKMAREAREIKIKLGLLPKPEPKVKLSNMMSVFENDQNITDPTAW
EKVVKDQVDLRKRKHLEENERRHEDAIKRRKEAVNMNVEKPTVYHCKVFQ
FKNLQNPKIRFKLKMNSKELSLKGLCLRIRDDGPGIIIVVGNEKSCKFYE
NLVMKRIKWNEDFELHTGDIKMDMHNNSISKTWEGYLQDCKFKGWFMKVC
NDQDSLLRTLGQFDSEHFYSPV
Ligand information
>5nrl Chain 4 (length=114) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auccuuaugcacgggaaauacgcauaucagugaggauucguccgagauug
uguuuuugcugguugaaauaauuauaacuccucauggucagacuauguag
ggaauuuuuggaau
Receptor-Ligand Complex Structure
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PDB5nrl Structure of a pre-catalytic spliceosome.
Resolution7.2 Å
Binding residue
(original residue number in PDB)		H239 R241 R245 R246 R249 E257 K267 K271 K273 E282 H308
Binding residue
(residue number reindexed from 1)		H146 R148 R152 R153 R156 E164 K174 K178 K180 E189 H215
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000387 spliceosomal snRNP assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005687 U4 snRNP
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071001 U4/U6 snRNP

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5nrl, PDBe:5nrl, PDBj:5nrl
PDBsum5nrl
PubMed28530653
UniProtQ03338|PRP3_YEAST U4/U6 small nuclear ribonucleoprotein PRP3 (Gene Name=PRP3)

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