Structure of PDB 5nrg Chain G Binding Site BS01

Receptor Information
>5nrg Chain G (length=142) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRQTFMANESNIERKWYVIDAEGQTLGRLSSEVASILRGKNKVTYTPHVD
TGDYVIVINASKIEFTGNKETDKVYYRHSNHPGGIKSITAGELRRTNPER
LIENSIKGMLPSTRLGEKQGKKLFVYGGAEHPHAAQQPENYE
Ligand information
>5nrg Chain X (length=2710) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccaauga
aggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuuga
uccagagauuuccgaauggggaaacccagcaugaguuaugucauguuauc
gauauguauacauagcauaucagaaggcacacccggagaacugaaacauc
uuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcga
gcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguugagga
cacucuaugaguuacaaaggacgacauuagacgaaucaucuggaaagaug
aaucaaagaagguaauaauccuguagucgaaaauguugucucucuugagu
ggauccugaguacgacggagcacgugaaauuccgucggaaucugggagga
ccaucuccuaaggcuaaauacucucuagugaccgauagugaaccaguacc
gugagggaaaggugaaaagcaccccggaaggggagugaaauagaaccuga
aaccgugugcuuacaaguagucagagcccguuaaugggugauggcgugcc
uuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagcagua
aauguggagccguagcgaaagcgagucugaauagggcguuuaguauuugg
ucguagacccgaaaccaggugaucuacccuuggucagguugaaguucagg
cugaauggaggaccgaaccgacuuacguugaaaagugagcggaugaacug
aggguagcggagaaauuccaaucgaaccuggagauagcugguucucuccg
aaauagcuuuagggcuagccucaagugaugauuauuggagguagagcacu
guuuggacgaggggguuaccgaauucagacaaacuccgaaugccaauuaa
uuuaacuugggagucagaacaugggugauaagguccguguucgaaaggga
aacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaa
ggauguggcguugcccagacaacuagcucauagucgagugacacugcgcc
gaaaauguaccggggcuaaacauauuaccgaagcuguggauuguccuugg
acaaugguaggagagcguucuaagggcguugaagcaugaucguaaggaca
uguggagcgcuuagaagugagaaugccggugugaguagcgaaagacgggu
gagaaucccguccaccgauugacuaagguuuccagaggaaggcucguccg
cucuggguuagucggguccuaagcugaggccgacaggcguaggcgaugga
uaacagguugauauuccuguaccaccuauaaucguaaucgauggggggac
gcaguaggauaggcgaagcgugcgauuggaugcacgucuaagcaguaagg
cugaguauccgguacucgaggcugagcugugauggggagagagucguuga
uuucacacugccgagaaaagccucuagauagauaggugcccguaccgcaa
accgacacagguagucaagaugagaauucuaaggugagcgagcgaacucu
cguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcu
cuuuaggguuaacgcccagaagagccgcagugaauaggcccaagcgacug
uuuaucaaaaacacaggucucugcuaaaccguaaggugauguauaggggc
ugacgccugcccggugcuggaagguuaagaggagugguuagcugcgaagc
uacgaaucgaagccccaguaaacggcggcccuaagguagcgaaauuccuu
gucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacuguc
ucaacgagagacucggugaaaucauaguaccugugaagaugcagguuacc
cgcgacaggacggaaagaccccguggagcuuuacuguagccugauauuga
aauucuggcuuucuaacccgcaccacuuaucguggugggagacaguguca
agcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgc
ucaaagguucccucagaaugguuggaaaucauucauagaguguaaaggca
uaagggagcuugacugcgagaccuacaagucgagcagggucgaaagacgg
acuuagugauccggugguuccgcauggaagggccaucgcucaacggauaa
aagcuaccccggggauaacaggcuuaucucccccaagaguucacaucgac
ggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagu
cggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggg
uucagaacgucgugagacaguucggucccuauccgucgugggcguaggaa
auuugagaggagcuguccuuaguacgagaggaccgggauggacauaccuc
ugguguaccaguugucgugccaacggcauagcuggguagcuaugugugga
cgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugaga
uuucccaacuugguuauaagaucccucaaagaugaugagguuaauagguu
cgagguggaagcauggugacauguggagcugacgaauacuaaucgaucga
agacuuaauc
Receptor-Ligand Complex Structure
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PDB5nrg Structural insights of lincosamides targeting the ribosome of Staphylococcus aureus.
Resolution3.442 Å
Binding residue
(original residue number in PDB)		M1 R2 T4 W16 T25 G27 R28 S31 R38 K40 P47 H48 Y54 T66 Y75 Y76 H78 S79 N80 G83 K86 R100 E103 S105 K107 G108 M109 P111 T113 R114 L115 K121 H133
Binding residue
(residue number reindexed from 1)		M1 R2 T4 W16 T25 G27 R28 S31 R38 K40 P47 H48 Y54 T66 Y75 Y76 H78 S79 N80 G83 K86 R100 E103 S105 K107 G108 M109 P111 T113 R114 L115 K121 H133
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0017148 negative regulation of translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5nrg, PDBe:5nrg, PDBj:5nrg
PDBsum5nrg
PubMed28973455
UniProtQ2FW38|RL13_STAA8 Large ribosomal subunit protein uL13 (Gene Name=rplM)

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