Structure of PDB 5l5d Chain G Binding Site BS01

Receptor Information

>5l5d Chain G (length=241) Species: 559292 (Saccharomyces cerevisiae S288C)

GYDRHITIFSPEGRLYQVEYAFKATNQTNINSLAVRGKDCTVVISQKKVP
DKLLDPTTVSYIFCISRTIGMVVNGPIPDARNAALRAKAEAAEFRYKYGY
DMPCDVLAKRMANLSQIYTQRAYMRPLGVILTFVSVDEELGPSIYKTDPA
GYYVGYKATATGPKQQEITTNLENHFKKSKIDHINEESWEKVVEFAITHM
IDALGTEFSKNDLEVGVATKDKFFTLSAENIEERLVAIAEQ

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5l5d Chain G Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5l5d A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit beta 5i.
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): T8 R122 A123 M125
• Binding residue (residue number reindexed from 1): T7 R121 A122 M124
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.4.25.1: proteasome endopeptidase complex.

Gene Ontology

Molecular Function

• GO:0003674 molecular_function
• GO:0005515 protein binding

Biological Process

• GO:0006511 ubiquitin-dependent protein catabolic process
• GO:0010499 proteasomal ubiquitin-independent protein catabolic process
• GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
• GO:0051603 proteolysis involved in protein catabolic process

Cellular Component

• GO:0000502 proteasome complex
• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0005839 proteasome core complex
• GO:0019773 proteasome core complex, alpha-subunit complex

External links

• PDB: RCSB:5l5d, PDBe:5l5d, PDBj:5l5d
• PDBsum: 5l5d
• PubMed: 27789522
• UniProt: P21243|PSA1_YEAST Proteasome subunit alpha type-1 (Gene Name=SCL1)