Structure of PDB 5gm6 Chain G Binding Site BS01

Receptor Information
>5gm6 Chain G (length=875) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHQLGGQYSIPQDLRENLQKEAARIGENEKDVLQEKMETRTVQNREDSYH
KRRFDMKFELNKDEKKERTLSMLLLKIKNGNTASRRTSMRILTDKAVTFG
PEMIFNRLLPILLDRSLEDQERHLMIKTIDRVLYQLGDLTKPYVHKILVV
AAPLLIDEDPMVRSTGQEIITNLSTVAGLKTILTVMRPDIENEDEYVRNV
TSRAAAVVAKALGVNQLLPFINAACHSRKSWKARHTGIKIVQQIGILLGI
GVLNHLTGLMSCIKDCLMDDHVPVRIVTAHTLSTLAENSYPYGIEVFNVV
LEPLWKGIRSHRGKVLSSFLKAVGSMIPLMDPEYAGYYTTEAMRIIRREF
DSPDDEMKKTILLVLQKCSAVESITPKFLREEIAPEFFQKFWVRRVALDR
PLNKVVTYTTVTLAKKLGCSYTIDKLLTPLRDEAEPFRTMAVHAVTRTVN
LLGTADLDERLETRLIDALLIAFQEQTNSDSIIFKGFGAVTVSLDIRMKP
FLAPIVSTILNHLKHKTPLVRQHAADLCAILIPVIKNCHEFEMLNKLNII
LYESLGEVYPEVLGSIINAMYCITSVMDLDKLQPPINQILPTLTPILRNK
HRKVEVNTIKFVGLIGKLAPTYAPPKEWMRICFELLELLKSTNKEIRRSA
NATFGFIAEAIGPHDVLVALLNNLKVQERQLRVCTAVAIGIVAKVCGPYN
VLPVIMNEYTTPETNVQNGVLKAMSFMFEYIGNMSKDYIYFITPLLEDAL
TDRDLVHRQTASNVITHLALNCSGTGHEDAFIHLMNLLIPNIFETSPHAI
MRILEGLEALSQALGPGLFMNYIWAGLFHPAKNVRKAFWRVYNNMYVMYQ
DAMVPFYPVTPDNNEEYIEELDLVL
Ligand information
>5gm6 Chain L (length=66) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
acgaaucucuuugccuuuuggcuuagaucaaguguaguaucuguucuuuu
caguguaacaacugaa
................................................<<
<<<<......>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5gm6 Structure of a yeast activated spliceosome at 3.5 angstrom resolution
Resolution3.5 Å
Binding residue
(original residue number in PDB)		T178 R182 R186 T738 S892 P893 P926 A927 K928
Binding residue
(residue number reindexed from 1)		T82 R86 R90 T642 S796 P797 P830 A831 K832
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0005515 protein binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0071004 U2-type prespliceosome
GO:0071013 catalytic step 2 spliceosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5gm6, PDBe:5gm6, PDBj:5gm6
PDBsum5gm6
PubMed27445306
UniProtP49955|SF3B1_YEAST U2 snRNP component HSH155 (Gene Name=HSH155)

[Back to BioLiP]