Structure of PDB 5f9f Chain G Binding Site BS01 |
| >5f9f Chain G (length=669) Species: 9606 (Homo sapiens)
[Search protein sequence]
[Download receptor structure]
[Download structure with residue number starting from 1]
[View receptor structure]
|
PFKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQ
KGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVE
NNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFN
YLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVI
ATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRI
CKREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKYN
DALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQELES
VSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEG
NPKLSFLKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSV
ADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIE
KEQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQPVPDK
ENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPKQF
SSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQT
LYSKWKDFHFEKIPFDPAE |
|
|
|
| Global view | Local view | Structure summary |
[Spin on]
[Spin off]
[Reset]
[High quality]
[Low quality]
[White background]
[Black background]
|
[Spin on]
[Spin off]
[Reset]
[High quality]
[Low quality]
[White background]
[Black background]
|
| PDB | 5f9f Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I. |
| Resolution | 2.601 Å |
Binding residue
(original residue number in PDB) | N298 Q299 I300 S325 G326 T347 Q349 K379 Q380 Q507 K508 E510 Q511 R546 K635 T636 R637 T662 G663 R664 T667 N668 T697 S698 K750 H830 F853 K858 I875 V886 K888 W908 K909 |
Binding residue
(residue number reindexed from 1) | N59 Q60 I61 S86 G87 T108 Q110 K140 Q141 Q258 K259 E261 Q262 R297 K386 T387 R388 T413 G414 R415 T418 N419 T448 S449 K501 H577 F600 K605 I622 V633 K635 W655 K656 |
| Binding affinity | PDBbind-CN: Kd=38.5nM |
|
|
| Enzyme Commision number |
3.6.4.13: RNA helicase. |
|
|
|
|
|
