Structure of PDB 5eya Chain G Binding Site BS01

Receptor Information
>5eya Chain G (length=86) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHMAELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQGSP
YLCPQCRAVYQARPQLHKNTVLCNVVEQFLQADLAR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5eya Chain G Residue 101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5eya Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		C28 H30 C50 C53
Binding residue
(residue number reindexed from 1)		C31 H33 C53 C56
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
6.3.2.n3: ISG15--protein ligase.
External links
PDB RCSB:5eya, PDBe:5eya, PDBj:5eya
PDBsum5eya
PubMed27425606
UniProtQ14258|TRI25_HUMAN E3 ubiquitin/ISG15 ligase TRIM25 (Gene Name=TRIM25)

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