Structure of PDB 5ajk Chain G Binding Site BS01

Receptor Information
>5ajk Chain G (length=137) Species: 10255 (Variola virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TNILDYLSTERDHVMMAVQYYMSKQRLDDLYRQLPTKTRSYIDIINMYCD
KVNNDYNRDMNIMYDMASTESFTVYDINNEVNTILMDNKGLGVRLATISF
ITELGKRCMNPVETIKMFTLLSHTICDDCFIDYITDI
Ligand information
>5ajk Chain H (length=23) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SSTMGQVGRQLAIIGDDINRRYD
Receptor-Ligand Complex Structure
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PDB5ajk Variola Virus F1L is a Bcl-2-Like Protein that Unlike its Vaccinia Virus Counterpart Inhibits Apoptosis Independent of Bim.
Resolution2.55 Å
Binding residue
(original residue number in PDB)		K114 D118 Y119 M126 M129 I140 E143 I147 G155 V156
Binding residue
(residue number reindexed from 1)		K51 D55 Y56 M63 M66 I77 E80 I84 G92 V93
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0033668 symbiont-mediated suppression of host apoptosis
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:5ajk, PDBe:5ajk, PDBj:5ajk
PDBsum5ajk
PubMed25766319
UniProtQ85365|PG045_VARV Apoptosis regulator OPG045 (Gene Name=OPG045)

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