Structure of PDB 4z94 Chain G Binding Site BS01

Receptor Information
>4z94 Chain G (length=307) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVVEHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTV
QLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQG
FESATFLGYFKSGLKYKKGGVASGFGKPVPDEEPNSTDVEETLERIKNND
PKLEEVNLNNIRNIPIPTLKAYAEALKENSYVKKFALANTRADDHVAFAI
AIMLKANKTITSLNLDSNHITGKGILAIFRALLQNNTLTELRFHNQRHIC
GGKTEMEIAKLLKENTTLLKLGYHFELAGPRMTVTNLLSRNMDKQRQKRL
QEQRQAQ
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4z94 Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4z94 How Leiomodin and Tropomodulin use a common fold for different actin assembly functions.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		D85 G90 A92
Binding residue
(residue number reindexed from 1)		D85 G90 A92
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005523 tropomyosin binding
GO:0051015 actin filament binding
Biological Process
GO:0051694 pointed-end actin filament capping

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Molecular Function
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Biological Process
External links
PDB RCSB:4z94, PDBe:4z94, PDBj:4z94
PDBsum4z94
PubMed26370058
UniProtP06396|GELS_HUMAN Gelsolin (Gene Name=GSN);
P28289;
P29536

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