Structure of PDB 4pki Chain G Binding Site BS01

Receptor Information
>4pki Chain G (length=306) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVVEHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTV
QLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQG
FESATFLGYFKSGLKYKKGGVASGFGYKPVPDEEPNSTDVEETLERIKNN
DPKLEEVNLNNIRNIPIPTLKAYAEALKENSYVKKFSIVGTRSNDPVAYA
LAEMLKENKVLKTLNVESNFISGAGILRLVEALPYNTSLVEMKIDNQSQP
LGNKVEMEIVSMLEKNATLLKFGYHFTQQGPRLRASNAMMNNNDLVRKRR
LADLTG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4pki Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4pki Actin cytoskeleton. Mechanism of actin filament pointed-end capping by tropomodulin.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		D136 G141 A143
Binding residue
(residue number reindexed from 1)		D85 G90 A92
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005523 tropomyosin binding
GO:0051015 actin filament binding
Biological Process
GO:0051694 pointed-end actin filament capping

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Molecular Function
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Biological Process
External links
PDB RCSB:4pki, PDBe:4pki, PDBj:4pki
PDBsum4pki
PubMed25061212
UniProtP06396|GELS_HUMAN Gelsolin (Gene Name=GSN);
P28289

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