Structure of PDB 4kvb Chain G Binding Site BS01

Receptor Information

>4kvb Chain G (length=155) Species: 262724 (Thermus thermophilus HB27)

ARRRRAEVRQLQPDLVYGDVLVTAFINKIMRDGKKNLAARIFYDACKIIQ
EKTGQEPLKVFKQAVENVKPRMEVRSRRVGGANYQVPMEVSPRRQQSLAL
RWLVQAANQRPERRAAVRIAHELMDAAEGKGGAVKKKEDVERMAEANRAY
AHYRW

Ligand information

>4kvb Chain A (length=1514)

uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaaga
caugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggac
gggugaguaacgcgugggugaccuacccggaagagggggacaacccgggg
aaacucgggcuaaucccccauguggacccgccccuugggguguguccaaa
gggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugg
gguaauggcccaccaaggcgacgacggguagccggucugagaggauggcc
ggccacaggggcacugagacacgggccccacuccuacgggaggcagcagu
uaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuugga
ggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccg
aggaggggacugacgguaccgggguaauagcgccggccaacuccgugcca
gcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcg
uaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcuc
aaccgugggggagcgugggauacgcucaggcuagacggugggagagggug
guggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgcc
gauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagc
guggggagcaaaccggauuagauacccggguaguccacgcccuaaacgau
gcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcg
cgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgg
gggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaag
aaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggu
gccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcuc
gugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccgu
uaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagc
gggaggaaggaggggacgacgucuggucagcauggcccuuacggccuggg
cgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacgg
ggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaaccc
gaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcgg
ugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcg
ggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguaggg
cccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcgg
cuggaucacuuucu

.....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<
<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>....
..<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<..
....>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...
<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<
<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>
>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>
>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<
<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.
....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....
<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<(
(.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<...
..>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<
<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>.......
....<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<
<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........
<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>
>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.
<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>...
.......<<<<<<<......<<<<<.....<<<<<<<....>>>>>>>..
..................>>>>>.<<<.<<<..<<<<<<.......<<<<
<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<
<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>
>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>.
..>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>
>..>>....>>>.....>>>>>>>......<....<<<<<<<........
>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>
>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<
<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>
>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>
>>............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4kvb Structural robustness of the ribosome inferred from the X-ray crystal structure of a 30S ribosomal subunit lacking ribosomal protein S17
• Resolution: 4.198 Å
• Binding residue (original residue number in PDB): A2 R3 R4 R5 A7 R10 N28 R32 D33 G34 K35 N37 L38 R41 R76 G81 G82 R94 R95 S98 R102 N109 R114 R115 A116 R119
• Binding residue (residue number reindexed from 1): A1 R2 R3 R4 A6 R9 N27 R31 D32 G33 K34 N36 L37 R40 R75 G80 G81 R93 R94 S97 R101 N108 R113 R114 A115 R118

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003723 RNA binding
• GO:0003729 mRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4kvb, PDBe:4kvb, PDBj:4kvb
• PDBsum: 4kvb
• UniProt: P62667|RS7_THET2 Small ribosomal subunit protein uS7 (Gene Name=rpsG)