Structure of PDB 3vgk Chain G Binding Site BS01

Receptor Information
>3vgk Chain G (length=311) Species: 455632 (Streptomyces griseus subsp. griseus NBRC 13350) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LTIGVDIGGTKIAAGVVDEEGRILSTFKVATPPTAEGIVDAICAAVAGAS
EGHDVEAVGIGAAGYVDDKRATVLFAPNIDWRHEPLKDKVEQRVGLPVVV
ENDANAAAWGEYRFGAGQGHDDVICITLGTGLGGGIIIGNKLRRGRFGVA
AEFGHIRVVPDGLLCGCGSQGCWEQYASGRALVRYAKQRANATPENAAVL
LGLGDGSVDGIEGKHISEAARQGDPVAVDSFRELARWAGAGLADLASLFD
PSAFIVGGGVSDEGELVLDPIRKSFRRWLIGGEWRPHAQVLAAQLGGKAG
LVGAADLARQG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3vgk Chain G Residue 322 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3vgk Substrate recognition mechanism and substrate-dependent conformational changes of an ROK family glucokinase from Streptomyces griseus
Resolution3.25 Å
Binding residue
(original residue number in PDB)
H157 C167 C169 C174
Binding residue
(residue number reindexed from 1)
H155 C165 C167 C172
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.1.2: glucokinase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004340 glucokinase activity
GO:0016301 kinase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0051156 glucose 6-phosphate metabolic process
Cellular Component
GO:0005737 cytoplasm

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Biological Process

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Cellular Component
External links
PDB RCSB:3vgk, PDBe:3vgk, PDBj:3vgk
PDBsum3vgk
PubMed22101842
UniProtB1VZT1

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