Structure of PDB 3jcm Chain G Binding Site BS01

Receptor Information
>3jcm Chain G (length=734) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PSFLDQEPPAGYVPGIGRGATGFKTLELKLAQKKKKRANEKSNVKRQFAD
LKESLAAVTESEWMDIPDATDFTRRNKRNRIQEQLNRKTYAAPDSLIPGN
VDLNKLTEEREKLLQSQIDENLRVNSLSDATLEDLQKMRTILKSYRKADP
TNPQGWIASARLEEKARKFSVAKKIIENGCQPRSSDIWLENIRLHESDVH
YCKTLVATAINFNPLLWFKAIDLESTTVNKYRVVRKALQEIPRDEGLWKL
AVSFEADKAQVIKMLEKATQFIPQSMDLLTAYTNLQSYHNAKMTSFRKIL
PQEPEIWIISTLLEERNNPDIPVDKLVSEGLLELSKNGYKATLSAKRAEA
LNDAPNSTCQAIVYAILEWLREYESELNNVDQILEKMPHSKKKLIQWDPC
DTVLWSRKMATESYHKIEELLAFFQEQTKNSDDIRANMRKSPGLLMMYVS
EYWKDTRQTLVLIDQIIDNLDLRFFKIKLLGRSRDFFQQTFSSLEDFKSG
TERLYYKYVNFNEEAIKFLNERCLKSICHKFFLQLGQIYHSMGEMSRETY
LSGTRLVPNCPLLWVSLSKIDEIDVRARSILDRGLLKNPDDVLFYIAKIQ
MEIRLGNLDQAELLVTQALQKFPSNALLWVEQIKLFKHGNKSSLKKTIFQ
DALRRTQNDHRVLLEIGVSFYAEAQYETSLKWLERALKKCYGDTWVWLFR
TYARLGKDTVDLYNMFDQCECTPREILLRLMNDK
Ligand information
>3jcm Chain E (length=85) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auccuuaugcacgggaaauacgcauaucagugaggauucguccgagauug
uguuuuugcugguuagggaauuuuuggaauaccuu
...................<<<<<.<<<.....<<<....>>>..>>>>>
>>>................................
Receptor-Ligand Complex Structure
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PDB3jcm The 3.8 angstrom structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis
Resolution3.8 Å
Binding residue
(original residue number in PDB)		N132 K133 R136 Q140 K144 S788 K791 T792
Binding residue
(residue number reindexed from 1)		N76 K77 R80 Q84 K88 S643 K646 T647
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0008150 biological_process
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071001 U4/U6 snRNP
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3jcm, PDBe:3jcm, PDBj:3jcm
PDBsum3jcm
PubMed26743623
UniProtP19735|PRP6_YEAST Pre-mRNA-splicing factor 6 (Gene Name=PRP6)

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