Structure of PDB 3jck Chain G Binding Site BS01

Receptor Information
>3jck Chain G (length=257) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KETVYISSIALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVNVVDVFAMPQ
SGTGVSVEAVDDVFQAKMMDMLKQTGRDQMVVGWYHSHPGFGCWLSSVDV
NTQKSFEQLNSRAVAVVVDPIQSVKGKVVIDAFRLIQALIHGLNRHYYSL
NIDYHKTAKETKMLMNLHKEQWQSGLKMYDYEEKEESNLAATKSMVKIAE
QYSKRIEEEKELTEEELKTRYVGRQDPKKHLSETADETLENNIVSVLTAG
VNSVAIK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3jck Chain G Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3jck Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		H109 H111 D122
Binding residue
(residue number reindexed from 1)		H86 H88 D99
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0070628 proteasome binding
GO:0140492 metal-dependent deubiquitinase activity
Biological Process
GO:0000266 mitochondrial fission
GO:0006508 proteolysis
GO:0016559 peroxisome fission
GO:0016579 protein deubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043248 proteasome assembly
GO:1902906 proteasome storage granule assembly
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0008541 proteasome regulatory particle, lid subcomplex
GO:0034515 proteasome storage granule

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3jck, PDBe:3jck, PDBj:3jck
PDBsum3jck
PubMed26744777
UniProtP43588|RPN11_YEAST Ubiquitin carboxyl-terminal hydrolase RPN11 (Gene Name=RPN11)

[Back to BioLiP]