Structure of PDB 2qa4 Chain G Binding Site BS01

Receptor Information

>2qa4 Chain G (length=125) Species: 2238 (Haloarcula marismortui)

RKTETIPEWKQEEVDAIVEMIESYESVGVVNIAGIPSRQLQDMRRDLHGT
AELRVSRNTLLERALDDVDDGLEDLNGYITGQVGLIGTDDNPFSLFQELE
ASKTPAPIGAGEVPNDIVIPEGDTG

Ligand information

>2qa4 Chain 0 (length=2753)

uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugcca
agcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuu
ccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaa
cugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguu
aguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggca
auguggugucagggcuaccucucaucagccgaccgucucgacgaagucuc
uuggaacagagcgugauacagggugacaaccccguacucgagaccaguac
gacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaa
cgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaac
aaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaaua
gagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucg
acgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgaugu
ucugucguacguuuugaaaacgagccagggagugugucugcauggcaagu
cuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggc
uugcccgagggccgccgucuucaagggcggggagccauguggacacgacc
cgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcac
guggaagucuguuagaguugguguccuacaauacccucucgugaucuaug
uguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaa
acaugucgaagcaugaccuccgccgagguagucugugagguagagcgacc
gauugguccugucaaacuccaaacuuacagacgccguuugacgcggggau
uccggugcgcgggguaagccuguguaccaggaggggaacaacccagagau
agguuaagguccccaaguguggauuaaguguaauccucugaagguggucu
cgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaaga
aaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucggg
acucaaauccaccaccgagaccuguccguaccacucauacugguaaucga
guagauuggcgcucuaauuggauggaaguaggggugaaaacuccuaugga
ccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugag
aaccccgacggccuaauggauaaggguuccucagcacugcugaucagcug
aggguuagccgguccuaagucauaccgcaacucgacuaugacgaaauggg
aaacggguuaauauucccgugccacuaugcagugaaaguugacgcccugg
ggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaag
ccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaa
ccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacac
agguguccauggcggcgaaagccaaggccugucgggagcaaccaacguua
gggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuc
cggaacggagcaggucgcagugacucggaagcucggacugucuaguaaca
acauaggugaccgcaaauccgcaaggacucguacggucacugaauccugc
ccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaa
cggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuu
gcaugaauggauuaaccagagcuucacugucccaacguugggcccgguga
acuguacauuccagugcggagucuggagacacccagggggaagcgaagac
ccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggagg
aggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaag
auaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagug
caagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugac
gcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauug
augacagaaaagcuacccuagggauaacagagucgucacucgcaagagca
cauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugc
ccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucg
ugagcuggguuuagaccgucgugagacaggucggcugcuaucuacugggu
guguaggugucugacaagaacgaccguauaguacgagaggaacuacgguu
gguggccacugguguaccgguuguucgagagagcacgugccggguagcca
cgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuugga
aaagagacaccgccgaggucccgcguacaagacgcggucgauagacucgg
ggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagac
caa

..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((.
.((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>
>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<...
..<<....>>......>>>>>.>.........<<.....>>...<<<<<.
....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.
....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<
<......>>>>.((......<<<.....))>>>....>>>>>>>......
>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......
<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))..........
.....<<....>>....))..........<<<.....>>>..........
.........>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<
<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>
>>>>>>...<<<.......>>>.<<<<<<....<<<<<<<<<<<<<..<<
<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<
..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<
.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>
>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>
>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<...
.<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....
<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..
>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<
<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<
<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>......
.<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))
>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>.
...>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...
>>>>>>>>....>.....>>>>>><<.....<........<<<<<<....
...>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>
>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>
..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<
<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<
<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...
>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<.....
.>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.
<<.........<.....<<<<<...............>>>>><<<<<<<<
<.....>>>>>>>>>............<<<<<<<<<..<<<.........
>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<
<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>
>>>><<...>>........<...........<<<<<.......>>>>>..
...>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>..
..>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......
<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>
>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<......
.....>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<.
..(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<
<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>
..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<...
....>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<
<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>...
...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>
>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>
><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>
.>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>..
.....>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<
<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>
>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2qa4 Structure of the base of the L7/L12 stalk of the Haloarcula marismortui large ribosomal subunit: Analysis of L11 movements
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): R7 K8 T9 I12 K16 V20 P42 S43 R44 Q47 R50 R60 V61 R63 N64 T65 R69 G87 Q88
• Binding residue (residue number reindexed from 1): R1 K2 T3 I6 K10 V14 P36 S37 R38 Q41 R44 R54 V55 R57 N58 T59 R63 G81 Q82

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding
• GO:0070180 large ribosomal subunit rRNA binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:2qa4, PDBe:2qa4, PDBj:2qa4
• PDBsum: 2qa4
• PubMed: 17599351
• UniProt: P15825|RL10_HALMA Large ribosomal subunit protein uL10 (Gene Name=rpl10)