Structure of PDB 1sgf Chain G Binding Site BS01

Receptor Information

>1sgf Chain G (length=232) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

IVGGFKCEKNSQPWHVAVYRYTQYLCGGVLLDPNWVLTAAHCYDDNYKVW
LGKNNLFKDEPSAQHRFVSKAIPHPGFNMSLMFLEYDYSNDLMLLRLSKP
ADITDTVKPITLPTEEPKLGSTCLASGWGSITPTKFQFTDDLYCVNLKLL
PNEDCAKAHIEKVTDAMLCAGEMDGGKDTCKGDSGGPLICDGVLQGITSW
GHTPCGEPDMPGVYTKLNKFTSWIKDTMAKNP

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

1sgf Chain A Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1sgf Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins.
Resolution	3.15 Å
Binding residue (original residue number in PDB)	H217 E222
Binding residue (residue number reindexed from 1)	H202 E207
Annotation score	4

Enzymatic activity

Catalytic site (original residue number in PDB)	G193 S195 G196
Catalytic site (residue number reindexed from 1)	G182 S184 G185
Enzyme Commision number	3.4.21.35: tissue kallikrein.

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0008083	growth factor activity
GO:0008236	serine-type peptidase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006508	proteolysis
GO:0007165	signal transduction

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Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1sgf, PDBe:1sgf, PDBj:1sgf
PDBsum	1sgf
PubMed	9351801
UniProt	P00756\|K1KB3_MOUSE Kallikrein 1-related peptidase b3 (Gene Name=Klk1b3)

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