Structure of PDB 1og0 Chain G Binding Site BS01

Receptor Information
>1og0 Chain G (length=342) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEEDVRILGYDPLASPALLQVQIPATPTSLETAKRGRREAIDIITGKDDR
VLVIVGPCSIHDLEAAQEYALRLKKLSDELKGDLSIIMRAYLEKPWKGLI
NDPDVNNTFNINKGLQSARQLFVNLTNIGLPIGSEMLDTISPQYLADLVS
FGAIGARTTESQLHRELASGLSFPVGFKNGTDGTLNVAVDACQAAAHSHH
FMSVTKHGVAAITTTKGNEHCFVILRGGKKGTNYDAKSVAEAKAQLPAGS
NGLMIDYSHGNSNKDFRNQPKVNDVVCEQIANGENAITGVMIESNINEGN
QIPAEAGLKYGVSITDACIGWETTEDVLRKLAAAVRQRREVN
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain1og0 Chain G Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1og0 Evolution of Feedback-Inhibited Beta /Alpha Barrel Isoenzymes by Gene Duplication and a Single Mutation.
Resolution2.7 Å
Binding residue
(original residue number in PDB)
C76 K112 H282 E316 D342
Binding residue
(residue number reindexed from 1)
C58 K94 H259 E293 D316
Annotation score1
Enzymatic activity
Enzyme Commision number 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.
Gene Ontology
Molecular Function
GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity
GO:0016740 transferase activity
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009058 biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:1og0, PDBe:1og0, PDBj:1og0
PDBsum1og0
PubMed
UniProtP32449|AROG_YEAST Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited (Gene Name=ARO4)

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